Magnesium-Catalyzed Hydroboration of Terminal and Internal Alkynes

被引：102
|
作者：
Magre, Marc [1 ]
Maity, Bholanath [2 ]
Falconnet, Alban [1 ]
Cavallo, Luigi [2 ]
Rueping, Magnus [1 ,2 ]
机构：
[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany
[2] KAUST, KCC, Thuwal 239556900, Saudi Arabia
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2019年 / 58卷 / 21期
关键词：
alkynes; DFT; hydroboration; magnesium; vinyl borane; CROSS-COUPLING REACTIONS; SELECTIVE HYDROBORATION; COMPLEXES; HYDRIDE; REACTIVITY; ALDEHYDES; ALKENES; ACIDS;
D O I：
10.1002/anie.201902188
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A magnesium-catalyzed hydroboration of alkynes providing good yields and selectivities for a wide range of terminal and symmetrical and unsymmetrical internal alkynes has been developed. The compatibility with many functional groups makes this magnesium catalyzed procedure attractive for late stage functionalization. Experimental mechanistic investigations and DFT calculations reveal insights into the reaction mechanism of the magnesium catalyzed protocol.
引用
收藏
页码：7025 / 7029
页数：5
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