Cardiopulmonary bypass time is an independent risk factor for acute kidney injury in emergent thoracic aortic surgery: a retrospective cohort study

被引：50

作者：

Xu, Shijun ^{[1
,2
]}

Liu, Jie ^{[3
]}

Li, Lei ^{[1
,2
]}

Wu, Zining ^{[1
,2
]}

Li, Jiachen ^{[1
,2
]}

Liu, Yongmin ^{[1
,2
]}

Zhu, Junming ^{[1
,2
]}

Sun, Lizhong ^{[1
,2
]}

Guan, Xinliang ^{[1
,2
]}

Gong, Ming ^{[1
,2
]}

Zhang, Hongjia ^{[1
,2
]}

机构：

[1] Capital Med Univ, Beijing Inst Heart Lung & Blood Vessel Dis, Beijing Lab Cardiovasc Precis Med, Beijing Anzhen Hosp,Beijing Aort Dis Ctr,Dept Car, 2 Anzhen St, Beijing 100029, Peoples R China

[2] Beijing Engn Res Ctr Vasc Prostheses, 2 Anzhen St, Beijing 100029, Peoples R China

[3] Chinese Peoples Liberat Army Gen Hosp, Dept Vasc & Endovasc Surg, Beijing 100853, Peoples R China

来源：

JOURNAL OF CARDIOTHORACIC SURGERY | 2019年 / 14卷 / 1期

基金：

国家重点研发计划; 美国国家科学基金会;

关键词：

Acute kidney injury; Aortic dissection; Cardiopulmonary bypass; Risk factor; Thoracic aortic surgery; ACUTE-RENAL-FAILURE; CARDIAC-SURGERY; DISSECTION; OUTCOMES; IMPACT; MORTALITY; OBESITY;

D O I：

10.1186/s13019-019-0907-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundThoracic aortic surgery and cardiopulmonary bypass are both associated with development of postoperative acute kidney injury. In this study, we undertook to investigate the relationship between cardiopulmonary bypass time and postoperative acute kidney injury in patients undergoing thoracic aortic surgery for acute DeBakey Type I aortic dissection.MethodsAll patients receiving thoracic aortic surgery for acute DeBakey Type I aortic dissection in Beijing Anzhen hospital from December 2015 to April 2017 were included. Cardiopulmonary bypass time was recorded during surgery. Acute kidney injury was defined based on the Kidney Disease Improving Global Outcomes criteria. A total of 115 consecutive patients were eventually analyzed.ResultsThe overall incidence of acute kidney injury was 53.0% (n=61). The average age was 47.810.7years; 74.8% were male. Mean cardiopulmonary bypass time was 211 +/- 56min. In-hospital mortality was 7.8%. Multivariate logistic regression revealed that cardiopulmonary bypass time was independently associated with the occurrence of postoperative acute kidney injury after adjust confounding factors (odds ratio=1.171; 95% confidence interval: 1.002-1.368; P=0.047).Conclusions p id=Par4 Cardiopulmonary bypass time is independently associated with an increased hazard of acute kidney injury after thoracic aortic surgery for acute DeBakey Type I aortic dissection. Further understanding of the mechanism of this association is crucial to the design of preventative strategies.

引用

页数：11

共 37 条

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