Francisella tularensis intracellular survival: to eat or to die

被引：15
作者：
Barel, Monique [1 ,2 ]
Charbit, Alain [1 ,2 ]
机构：
[1] Univ Paris 05, Sorbonne Paris Cite, F-75993 Paris 14, France
[2] INSERM, UnitE PathogEnie Infect Syst, U1002, Paris, France
来源：
MICROBES AND INFECTION | 2013年 / 15卷 / 14-15期
关键词：
Francisella tularensis; Intracellular parasitism; Nutritional immunity; OUTER-MEMBRANE VESICLES; PATHOGENICITY ISLAND; PHAGOSOMAL ESCAPE; HUMAN MACROPHAGES; NADPH OXIDASE; IN-VITRO; MURINE MACROPHAGES; CYTOSOLIC BACTERIA; HUMAN NEUTROPHILS; VI SECRETION;
D O I：
10.1016/j.micinf.2013.09.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Francisella tularensis is a highly infectious facultative intracellular bacterium causing the zoonotic disease tularemia. Numerous attributes required for E tularensis intracellular multiplication have been identified recently. However, the mechanisms by which the majority of them interfere with the infected host are still poorly understood. The following review summarizes our current knowledge on the different steps of Francisella intramacrophagic life cycle and expands on the importance of nutrient acquisition. (C) 2013 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
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收藏
页码：989 / 997
页数：9
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