Antiplatelet actions of aporphinoids from formosan plants

被引：26
作者：
Chia, YC
Chen, KS
Chang, YL
Teng, CM
Wu, YC [1 ]
机构：
[1] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[2] Tajen Inst Technol, Ping Tung Hsien 907, Taiwan
[3] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei 100, Taiwan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 23期
关键词：
alkaloids; anticoagulants; natural products; plants;
D O I：
10.1016/S0960-894X(99)00593-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Seventeen aporphines were tested for antiplatelet activity. L-(+)-hernovine HCl and 7-hydroxydehydrothalicsimidine strongly inhibited platelet aggregation induced by adenosine 5'-diphosphate (ADP), arachidonic acid (AA), collagen, and platelet-activating factor (PAF). The latter showed the strongest antiplatelet activity with an IC50 of 70.4 mu M against AA-induced platelet aggregation. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3295 / 3300
页数：6
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