Cellular therapies for the endometrium: An update

被引：17

作者：

Queckborner, Suzanna ^{[1
,2
]}

Davies, Lindsay C. ^{[3
]}

von Grothusen, Carolina ^{[1
,2
]}

Santamaria, Xavier ^{[4
]}

Simon, Carlos ^{[4
]}

Gemzell-Danielsson, Kristina ^{[1
,2
]}

机构：

[1] Karolinska Inst, Div Obstet & Gynecol, Dept Womens & Childrens Hlth, Solna, Sweden

[2] Karolinska Univ Hosp, Solna, Sweden

[3] Karolinska Inst, Dept Lab Med, Huddinge, Sweden

[4] Univ Valencia, INCLIVA, Dept Obstet & Gynecol, Valencia, Spain

来源：

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA | 2019年 / 98卷 / 05期

关键词：

Asherman's syndrome; cell therapy; endometrial disease; female infertility; MESENCHYMAL STROMAL CELLS; PLATELET-RICH PLASMA; STEM-CELLS; BONE-MARROW; INTERNATIONAL-SOCIETY; ASHERMANS-SYNDROME; TRANSPLANTATION; RECEPTIVITY; MSCS;

D O I：

10.1111/aogs.13598

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

An update on the current state of endometrial cell therapies in terms of cell types, mechanisms of action, delivery, safety, regulatory frameworks and future perspectives. This review focuses on clinical trials using angiogenesis-promoting therapies and stromal therapies piloted in the last 10 years for alleviating Asherman's syndrome and long-term infertility. All studies present promising preliminary results, indicating increased endometrial thickness and resumed menstruation. Further characterization of individual cell products, their mode of action and larger clinical trials will be essential to establishing cell therapy as a viable option for the treatment of infertility and fertility preservation.

引用

页码：672 / 677

页数：6

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