HMGA2 Contributes to Distant Metastasis and Poor Prognosis by Promoting Angiogenesis in Oral Squamous Cell Carcinoma

被引：42

作者：

Sakata, Junki ^{[1
]}

Hirosue, Akiyuki ^{[1
]}

Yoshida, Ryoji ^{[1
]}

Kawahara, Kenta ^{[1
]}

Matsuoka, Yuichiro ^{[1
]}

Yamamoto, Tatsuro ^{[1
]}

Nakamoto, Masafumi ^{[1
]}

Hirayama, Masatoshi ^{[1
]}

Takahashi, Nozomu ^{[1
]}

Nakamura, Takuya ^{[1
]}

Arita, Hidetaka ^{[1
]}

Nakashima, Hikaru ^{[1
]}

Nagata, Masashi ^{[1
]}

Hiraki, Akimitsu ^{[2
]}

Shinohara, Masanori ^{[1
]}

Nakayama, Hideki ^{[1
]}

机构：

[1] Kumamoto Univ, Dept Oral & Maxillofacial Surg, Fac Life Sci, Kumamoto 8608556, Japan

[2] Fukuoka Dent Coll, Sect Oral Oncol, Dept Oral & Maxillofacial Surg, Fukuoka, Fukuoka 8140193, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 10期

基金：

日本学术振兴会;

关键词：

angiogenesis; HMGA2; metastasis; oral squamous cell carcinoma; prognosis; MESENCHYMAL TRANSITION; EXPRESSION; CANCER; ACTIVATION; PROTEINS; SURVIVAL; GENE; EMT;

D O I：

10.3390/ijms20102473

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The highly malignant phenotype of oral squamous cell carcinoma (OSCC), including the presence of nodal and distant metastasis, reduces patient survival. High-mobility group A protein 2 (HMGA2) is a non-histone chromatin factor that is involved in advanced malignant phenotypes and poor prognosis in several human cancers. However, its biological role in OSCC remains to be elucidated. The purpose of this study was to determine the clinical significance and role of HMGA2 in the malignant potential of OSCC. We first investigated the expression pattern of HMGA2 and its clinical relevance in 110 OSCC specimens using immunohistochemical staining. In addition, we examined the effects HMGA2 on the regulation of vascular endothelial growth factor (VEGF)-A, VEGF-C, and fibroblast growth factor (FGF)-2, which are related to angiogenesis, in vitro. High expression of HMGA2 was significantly correlated with distant metastasis and poor prognosis. Further, HMGA2 depletion in OSCC cells reduced the expression of angiogenesis genes. In OSCC tissues with high HMGA2 expression, angiogenesis genes were increased and a high proportion of blood vessels was observed. These findings suggest that HMGA2 plays a significant role in the regulation of angiogenesis and might be a potential biomarker to predict distant metastasis and prognosis in OSCC.

引用

页数：15

共 42 条

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