Maltitol inhibits small intestinal glucose absorption and increases insulin mediated muscle glucose uptake ex vivo but not in normal and type 2 diabetic rats

被引：11
作者：
Chukwuma, Chika Ifeanyi [1 ]
Ibrahim, Mohammed Auwal [1 ,2 ]
Islam, Md. Shahidul [1 ]
机构：
[1] Univ KwaZulu Natal, Sch Life Sci, Dept Biochem, Westville Campus, ZA-4000 Durban, South Africa
[2] Ahmadu Bello Univ, Dept Biochem, Zaria, Nigeria
来源：
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION | 2017年 / 68卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
Intestinal glucose absorption; muscle glucose uptake; type; 2; diabetes; maltitol; rats; DIGESTIVE TOLERANCE; SERUM-INSULIN; XYLITOL; FRUCTOSE; CONSUMPTION; MECHANISM; PREVENTION; RESISTANCE; SORBITOL; MODEL;
D O I：
10.1080/09637486.2016.1216527
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
This study investigated the effects of maltitol on intestinal glucose absorption and muscle glucose uptake using ex vivo and in vivo experimental models. The ex vivo experiment was conducted in isolated jejunum and psoas muscle from normal rats. The in vivo study investigated the effects of a single bolus dose of maltitol on gastric emptying, intestinal glucose absorption and digesta transit in normal and type 2 diabetic rats. Maltitol inhibited glucose absorption in isolated rat jejunum and increased glucose uptake in isolated rat psoas muscle in the presence of insulin but not in the absence of insulin. In contrast, maltitol did not significantly (p > 0.05) alter small intestinal glucose absorption or blood glucose levels as well as gastric emptying and digesta transit in normal or type 2 diabetic rats. The results suggest that maltitol may not be a suitable dietary supplement for anti-diabetic food and food products to improve glycemic control.
引用
收藏
页码：73 / 81
页数：9
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