FREQUENCY OF DISTRIBUTION OF INFLAMMATORY CYTOKINES IL-1, IL-6 AND TNF-α GENE POLYMORPHISM IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA

被引：0
作者：
Popko, K. [1 ]
Gorska, E. [1 ]
Potapinska, O. [1 ]
Wasik, M. [1 ]
Stoklosa, A. [2 ]
Plywaczewski, R. [2 ]
Winiarska, M. [1 ]
Gorecka, D. [2 ]
Sliwinski, P. [2 ]
Popko, M. [3 ]
Szwed, T. [3 ]
Demkow, U. [1 ]
机构：
[1] Warsaw Med Univ, Dept Lab Diagnost & Clin Immunol Dev Age, PL-00576 Warsaw, Poland
[2] Inst TB & Lung Dis, Clin Pulm Dis 2, Warsaw, Poland
[3] Bielanski Hosp, Dept Gastroenterol, Warsaw, Poland
来源：
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2008年 / 59卷
关键词：
inflammatory cytokines; IL-6; IL-1; TNF-alpha; gene polymorphism; obesity; OSAS;
D O I：
暂无
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Obesity is one of the most commonly identified factors for the obstructive sleep apnea syndrome (OSAS). Adipose tissue is the source of many cytokines, among them there are IL-6, IL-1, and TNF-alpha. The level of inflammatory cytokines increases in people with OSAS and obesity. The aim of this study was to evaluate the distribution of genotypes in inflammatory cytokine genes in people with obesity-related OSAS. The examined group consisted of 102 person with obesity related-OSAS and 77 normal weight person without OSAS. Genotyping of DNA sequence variation was carried out by restriction enzyme (IL-1: Taq I, IL-6: Lwe I, TNF-alpha: Nco I) analysis of PCR amplified DNA. The study revealed a significant correlation between polymorphism located in the promoter region of inflammatory cytokine genes and obesity-related OSAS.
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页码：607 / 614
页数：8
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