Precisely localized LTD in the neocortex revealed by infrared-guided laser stimulation

被引：66

作者：

Dodt, HU ^{[1
]}

Eder, M ^{[1
]}

Frick, A ^{[1
]}

Zieglgänsberger, W ^{[1
]}

机构：

[1] Max Planck Inst Psychiat, D-80804 Munich, Germany

来源：

SCIENCE | 1999年 / 286卷 / 5437期

关键词：

D O I：

10.1126/science.286.5437.110

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In a direct approach to elucidate the origin of long-term depression (LTD), glutamate was applied onto dendrites of neurons in rat neocortical slices. An infrared-guided laser stimulation was used to release glutamate from caged glutamate in the focal spot df an ultraviolet laser. A burst of light flashes caused an LTD-like depression of glutamate receptor responses, which was highly confined to the region of "tetanic" stimulation (<10 micrometers). A similar depression of glutamate receptor responses was observed during LTD of synaptic transmission. A spatially highly specific postsynaptic mechanism tan account for the LTD induced by glutamate release.

引用

收藏

页码：110 / 113

页数：4

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