Marked improvement in survival among adult Croatian AIDS patients after the introduction of highly active antiretroviral treatment

被引:0
作者
Begovac, J
Lisic, M
Lukas, D
Maretic, T
Kniewald, T
Novotny, TE
机构
[1] Univ Zagreb, Univ Hosp Infect Dis Dr Fran Mihaljevic, Dept HIV AIDS, HR-10002 Zagreb, Croatia
[2] Univ Calif San Francisco, San Francisco, CA 94143 USA
关键词
AIDS; survival; protease inhibitors; HAART; Croatia;
D O I
暂无
中图分类号
Q98 [人类学];
学科分类号
030303 ;
摘要
We compared the survival of patients following the first AIDS event in Croatia from the period 1986-1996 to the period 1997-2000. A total of 72 (81.8%) out of 88 patients from 1986-1996 and 18 (32.1%) out of 56 from 1997-2000 died. Survival following the first AIDS-defining illness markedly improved in the period 1997-2000 compared to the period 1986-1996 (adjusted Hazard Ratio (HR) for patients surviving more than 6 months: 0.11, 95% confidence interval (95% CI) =0.04-0.29). A CD4(+) cell count of < 100 x 10(6)/L was an independent risk factor for patients surviving up to 2 years (adjusted HR=1.96, 95% CI=1.1-3.43, p=0.02). Patients with tuberculosis or fungal infections had a longer survival when compared to other diagnosis (adjusted HR=0.53, 95% CI=0.32-0.90, p=0.01). However, despite dramatic survival benefit of combination antiretroviral therapy, mortality at six months following the first AIDS event was similar in the two study periods and the one-year probability of death was still substantial (27.2%) in the period 1997-2000.
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页码:175 / 179
页数:5
相关论文
共 19 条
[1]   Survival of AIDS patients in Croatia prior to the introduction of combined antiretroviral therapy with protease inhibitors [J].
Begovac, J ;
Kniewald, T ;
Ugarkovic, N ;
Lisic, M ;
Sonicki, Z ;
Jazbec, A .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2000, 16 (08) :741-744
[2]  
Begovac J, 2001, COLLEGIUM ANTROPOL, V25, P111
[3]   Prognostic factors correlated with survival in AIDS patients [J].
Casari, S ;
Donisi, A ;
Paraninfo, G ;
Tomasoni, D ;
Palvarini, L ;
Nasta, P ;
Bergamasco, A ;
Cadeo, GP ;
Carosi, G .
EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1999, 15 (08) :691-698
[4]  
CASCADE Collaboration, 2000, LANCET, V355, P1158, DOI 10.1016/S0140-6736(00)02069-9
[5]   Impact of opportunistic disease on survival in patients with HIV infection [J].
Chaisson, RE ;
Gallant, JE ;
Keruly, JC ;
Moore, RD .
AIDS, 1998, 12 (01) :29-33
[6]   Regional survival differences across Europe in HIV-positive people: the EuroSIDA study [J].
Chiesi, A ;
Mocroft, A ;
Dally, LG ;
Miller, V ;
Katlama, C ;
Ledergerber, B ;
Pedersen, C ;
Phillips, AN ;
Arcieri, R ;
Lundgren, JD .
AIDS, 1999, 13 (16) :2281-2288
[7]   Effectiveness of potent antiretroviral therapy on time to AIDS and death in men with known HIV infection duration [J].
Detels, R ;
Muñoz, A ;
McFarlane, G ;
Kingsley, LA ;
Margolick, JB ;
Giorgi, J ;
Scharager, LD ;
Phair, JP .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (17) :1497-1503
[8]  
*EUR CTR EP MON AI, 1993, Q REPORT, V37, P23
[9]  
Hogg RS, 1999, CAN MED ASSOC J, V160, P659
[10]   Improving survival following AIDS in Australia, 1991-1996 [J].
Li, YM ;
McDonald, AM ;
Dore, GJ ;
Kaldor, JM .
AIDS, 2000, 14 (15) :2349-2354