Origin of genes

被引：200
作者：
Gilbert, W
deSouza, SJ
Long, MY
机构：
[1] Dept. of Molec. and Cellular Biology, Biological Laboratories, Harvard University, Cambridge, MA 02138
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 15期
关键词：
intron; exon; module; evolution;
D O I：
10.1073/pnas.94.15.7698
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We discuss two tests of the hypothesis that the first genes crc re assembled from exons, The hypothesis of exon shuffling in the progenote predicts that intron phases will be correlated so that exons will be an integer number of codons and predicts that the exons will he correlated with compact regions of polypeptide chain, These predictions have been tested on ancient conserved proteins (proteins without introns in prokaryotes hut with introns in eukaryotes) and hold with high statistical significance. We conclude that introns are correlated with computer features of proteins 15-, 22-, or 30-amino acid residues long, as was predicted by ''The Exon Theory of Genes.''
引用
收藏
页码：7698 / 7703
页数：6
相关论文
共 17 条
[1]  
CAVALIERSMITH CCF, 1978, J CELL SCI
[2]   INTRON-EXON SPLICE JUNCTIONS MAP AT PROTEIN SURFACES [J].
CRAIK, CS ;
SPRANG, S ;
FLETTERICK, R ;
RUTTER, WJ .
NATURE, 1982, 299 (5879) :180-182
[3]   Intron positions correlate with module boundaries in ancient proteins [J].
deSouza, SJ ;
Long, M ;
Schoenbach, L ;
Roy, SW ;
Gilbert, W .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (25) :14632-14636
[4]   GENES IN PIECES - WERE THEY EVER TOGETHER [J].
DOOLITTLE, WF .
NATURE, 1978, 272 (5654) :581-582
[5]   PSEUDOGENES IN YEAST [J].
FINK, GR .
CELL, 1987, 49 (01) :5-6
[6]  
Gesteland R.E., 1993, The RNA World
[7]   ON THE ANTIQUITY OF INTRONS [J].
GILBERT, W ;
MARCHIONNI, M ;
MCKNIGHT, G .
CELL, 1986, 46 (02) :151-154
[8]   ORIGIN OF LIFE - THE RNA WORLD [J].
GILBERT, W .
NATURE, 1986, 319 (6055) :618-618
[9]   THE EXON THEORY OF GENES [J].
GILBERT, W .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1987, 52 :901-905
[10]   CORRELATION OF DNA EXONIC REGIONS WITH PROTEIN STRUCTURAL UNITS IN HEMOGLOBIN [J].
GO, M .
NATURE, 1981, 291 (5810) :90-92
12