Associations of Genetic Variations in ABCA1 and Lifestyle Factors with Coronary Artery Disease in a Southern Chinese Population with Dyslipidemia: A Nested Case-Control Study

被引:6
作者
Zhao, Tian-Yu [1 ,2 ]
Lei, Song [1 ,2 ]
Huang, Liu [1 ]
Wang, Yi-Nan [1 ]
Wang, Xiao-Ni [1 ]
Zhou, Ping-Pu [1 ]
Xu, Xiao-Jun [1 ]
Zhang, Long [1 ]
Xu, Liang-Wen [1 ]
Yang, Lei [1 ]
机构
[1] Hangzhou Normal Univ, Sch Med, Hangzhou 310000, Zhejiang, Peoples R China
[2] Shihezi Univ, Sch Med, Shihezi 832000, Peoples R China
基金
美国国家科学基金会;
关键词
ABCA1; lifestyle; coronary artery disease; interaction; haplotype; HEART-DISEASE; PHYSICAL-ACTIVITY; CARDIOVASCULAR-DISEASE; HDL-C; RISK; ATHEROSCLEROSIS; APOLIPOPROTEINS; RECOMMENDATIONS; POLYMORPHISMS; METAANALYSIS;
D O I
10.3390/ijerph16050786
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Coronary artery disease has become a major health concern over the past several decades. We aimed to explore the association of single nucleotide polymorphisms (SNPs) in the ATP-binding cassette subfamily A member 1 (ABCA1) and lifestyle factors with coronary artery disease (CAD) in dyslipidemia. This nested case-control study included 173 patients with CAD and 500 matched control individuals (1:3, case: control) from a district in southern China. We collected medical reports, lifestyle details, and blood samples of individuals with dyslipidemia and used the polymerase chain reaction-ligase detection reaction method to genotype the SNPs. The CC genotype of the additive and recessive models of rs4149339, together with regular intake of fried foods or dessert, increased the risk of CAD (adjusted odd ratio (OR) = 1.91, p = 0.030; adjusted OR = 1.97, p = 0.017; adjusted OR = 1.80, p = 0.002; adjusted OR = 1.98, p = 0.001). The AT + AA genotype of the dominant model of rs4743763 and moderate/heavy physical activity reduced the risk of CAD (adjusted OR = 0.66, p = 0.030; adjusted OR = 0.44, p = 0.001). The CT + CC genotype of the dominant model of rs2472386 reduced the risk of CAD only in males (adjusted OR = 0.36, p = 0.001). The interaction between rs4149339 and rs4743763 of ABCA1 and haplotype CTT (comprising rs4149339, rs4743763, and rs2472386) appeared to increase the risk of CAD (relative excess risk due to interaction (RERI) = 3.19, p = 0.045; OR = 1.49, p = 0.019). Polymorphisms of rs4149339, rs4743763 and rs2472386 in ABCA1 and three lifestyle factors (physical activity, fried food intake, and dessert intake) were associated with CAD in people with dyslipidemia in southern China. These results provide the theoretical basis for gene screening and the prevention of chronic cardiovascular diseases.
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页数:13
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共 38 条
  • [1] [Anonymous], 2000, JAMA, DOI DOI 10.1001/jama.2009.1619
  • [2] [Anonymous], 2016, LIPIDS HLTH DIS
  • [3] Berkinbayev S, 2014, J Genet Syndr Gene Ther, V5, P216
  • [4] Aspirin Use for the Primary Prevention of Cardiovascular Disease and Colorectal Cancer: US Preventive Services Task Force Recommendation Statement
    Bibbins-Domingo, Kirsten
    [J]. ANNALS OF INTERNAL MEDICINE, 2016, 164 (12) : 836 - U103
  • [5] Bornaun H, 2017, ARCH ARGENT PEDIATR, V115, P50, DOI [10.5546/aap.2017.eng.50, 10.5546/aap.2017.50]
  • [6] Dean M, 2001, J LIPID RES, V42, P1007
  • [7] Influence of retirement on leisure-time physical activity - The atherosclerosis risk in communities study
    Evenson, KR
    Rosamond, WD
    Cai, JW
    Diez-Roux, AV
    Brancati, FL
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2002, 155 (08) : 692 - 699
  • [8] Significant interaction of APOE rs4420638 polymorphism with HDL-C and APOA-I levels in coronary heart disease in Han Chinese men
    Huang, Y.
    Ye, H. D.
    Gao, X.
    Nie, S.
    Hong, Q. X.
    Ji, H. H.
    Sun, J.
    Zhou, S. J.
    Fei, B.
    Li, K. Q.
    Zhao, J. K.
    Wang, Z. P.
    Xu, M. Q.
    Duan, S. W.
    [J]. GENETICS AND MOLECULAR RESEARCH, 2015, 14 (04) : 13414 - 13424
  • [9] National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 1-Full Report
    Jacobson, Terry A.
    Ito, Matthew K.
    Maki, Kevin C.
    Orringer, Carl E.
    Bays, Harold E.
    Jones, Peter H.
    McKenney, James M.
    Grundy, Scott M.
    Gill, Edward A.
    Wild, Robert A.
    Wilson, Don P.
    Brown, W. Virgil
    [J]. JOURNAL OF CLINICAL LIPIDOLOGY, 2015, 9 (02) : 129 - 169
  • [10] Lipoprotein (a) and Cardiovascular Risk: The Show Must go on
    Katsiki, Niki
    Al-Rasadi, Khalid
    Mikhailidis, Dimitri P.
    [J]. CURRENT MEDICINAL CHEMISTRY, 2017, 24 (10) : 989 - 1006