A label-free aptasensor for the detection of ATP based on turn-on fluorescence DNA-templated silver nanoclusters

被引：6

作者：

Zhang, Baozhu ^{[1
]}

Yang, Ziyao ^{[1
]}

Li, Yuxia ^{[1
]}

Ma, Ling ^{[1
]}

Li, Fenfang ^{[1
]}

Lv, Xiuqing ^{[1
]}

Wen, Guangming ^{[1
]}

机构：

[1] Jinzhong Univ, Dept Chem & Chem Engn, Yuci 030619, Peoples R China

来源：

RSC ADVANCES | 2022年 / 12卷 / 46期

关键词：

ADENOSINE-TRIPHOSPHATE; METAL; PROBE; NANOPARTICLES; METABOLITES; LIGHT;

D O I：

10.1039/d2ra04636a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A label-free aptasensor has been fabricated in order to detect adenosine triphosphate (ATP) using turn-on fluorescence DNA-Ag NCs. The fluorescence of the DNA-Ag NCs could increase remarkably with the addition of ATP mainly because ATP specifically interacts with its aptamer to change the microenvironment of the darkish DNA-Ag NCs located at one terminus or two termini due to the conformational alteration of the aptamer structure. The proposed sensor can detect ATP in a linear range of 6-27 mM with a good detection limit of 5.0 mu M. Additionally, the proposed method succeeded in detecting ATP in fetal bovine serum.

引用

页码：30024 / 30029

页数：6

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