Determination of Moisture Content in 5-Fluorouracil using Diffuse Reflectance Infrared Spectroscopy

被引：0
|
作者：
Singh, Parul [1 ]
Jangir, Deepak Kumar [1 ]
Mehrotra, Ranjana [1 ]
Kandpal, H. C. [1 ]
机构：
[1] Natl Phys Lab, New Delhi 110012, India
来源：
PERSPECTIVES IN VIBRATIONAL SPECTROSCOPY | 2008年 / 1075卷
关键词：
Moisture Content; Infrared Spectroscopy; Diffuse Reflectance; 5-Fluorouracil;
D O I：
暂无
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Determination of moisture content in pharmaceuticals is very important, as moisture is mainly responsible for the degradation of drugs. The degraded drug has not only reduced efficacy but is also hazardous for health. The objective of the present work is to replace the Karl Fischer (KF) titration method used for moisture analysis with a method that is rapid, involves no toxic materials and is more effective. Diffuse reflectance infrared spectroscopy, which is explored as a potential alternate for various applications. is investigated for moisture analysis in 5-Fluorouracil, an anticancer drug.
引用
收藏
页码：172 / 174
页数：3
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