Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer

被引：13
作者：
Vermani, Litika [1 ]
Kumar, Rajeev [2 ]
Kannan, Rengaswamy R. [2 ]
Deka, Monoj K. [3 ]
Talukdar, Anuradha [2 ]
Kumar, Nachimuthu S. [1 ]
机构：
[1] Mizoram Univ, Biotechnol, Aizawl 796004, Mizoram, India
[2] Cachar Canc Hosp & Res Ctr, Res, Silchar 788015, India
[3] Silchar Med Coll & Hosp, Silchar 788015, India
来源：
BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 14期
关键词：
ALDH1; cancer stem cell; E-cadherin; epithelial mesenchymal transition; twist; Vimentin; young colorectal cancer; EPITHELIAL-MESENCHYMAL TRANSITION; LYMPH-NODE METASTASIS; PROGNOSTIC MARKER; STEM-CELLS; EMT; YOUNG; OVEREXPRESSION; SIGNATURE; EPCAM;
D O I：
10.2217/bmm-2020-0206
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim:To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age.Materials & methods:Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples.Results:ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001).Conclusion:High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer.
引用
收藏
页码：1371 / 1382
页数：12
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