Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer

被引：13
作者：
Vermani, Litika [1 ]
Kumar, Rajeev [2 ]
Kannan, Rengaswamy R. [2 ]
Deka, Monoj K. [3 ]
Talukdar, Anuradha [2 ]
Kumar, Nachimuthu S. [1 ]
机构：
[1] Mizoram Univ, Biotechnol, Aizawl 796004, Mizoram, India
[2] Cachar Canc Hosp & Res Ctr, Res, Silchar 788015, India
[3] Silchar Med Coll & Hosp, Silchar 788015, India
来源：
BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 14期
关键词：
ALDH1; cancer stem cell; E-cadherin; epithelial mesenchymal transition; twist; Vimentin; young colorectal cancer; EPITHELIAL-MESENCHYMAL TRANSITION; LYMPH-NODE METASTASIS; PROGNOSTIC MARKER; STEM-CELLS; EMT; YOUNG; OVEREXPRESSION; SIGNATURE; EPCAM;
D O I：
10.2217/bmm-2020-0206
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim:To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age.Materials & methods:Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples.Results:ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001).Conclusion:High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer.
引用
收藏
页码：1371 / 1382
页数：12
相关论文
共 50 条
[21]   Dysregulated expression of Slug, vimentin, and E-cadherin correlates with poor clinical outcome in patients with basal-like breast cancer [J].
Liu, Tong ;
Zhang, Xianyu ;
Shang, Ming ;
Zhang, Youxue ;
Xia, Bingshu ;
Niu, Ming ;
Liu, Yang ;
Pang, Da .
JOURNAL OF SURGICAL ONCOLOGY, 2013, 107 (02) :188-194
[22]   Role of TWIST2, E-cadherin and Vimentin in epithelial ovarian carcinogenesis and prognosis and their interaction in cancer progression [J].
Li, X. ;
Yang, J. ;
Wang, X. ;
Li, X. ;
Liang, J. ;
Xing, H. .
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2016, 37 (01) :100-108
[23]   Loss of E-Cadherin Expression Is Associated with a Poor Prognosis in Stage III Colorectal Cancer [J].
Yun, Jung-A ;
Kim, Seok-Hyung ;
Hong, Hye Kyung ;
Yun, Seong Hyeon ;
Kim, Hee Cheol ;
Chun, Ho-Kyung ;
Cho, Yong Beom ;
Lee, Woo Yong .
ONCOLOGY, 2014, 86 (5-6) :318-328
[24]   High vimentin expression with E-cadherin expression loss predicts a poor prognosis after resection of grade 1 and 2 pancreatic neuroendocrine tumors [J].
Bo Zhou ;
Jie Xiang ;
Ming Jin ;
Xiang Zheng ;
Guogang Li ;
Sheng Yan .
BMC Cancer, 21
[25]   High vimentin expression with E-cadherin expression loss predicts a poor prognosis after resection of grade 1 and 2 pancreatic neuroendocrine tumors [J].
Zhou, Bo ;
Xiang, Jie ;
Jin, Ming ;
Zheng, Xiang ;
Li, Guogang ;
Yan, Sheng .
BMC CANCER, 2021, 21 (01)
[26]   Loss of E-cadherin expression in early gastric cancer [J].
Blok, P ;
Craanen, ME ;
Dekker, W ;
Tytgat, GNJ .
HISTOPATHOLOGY, 1999, 34 (05) :410-415
[27]   Expression of E-cadherin and catenins in early gastric cancer [J].
Joo, YE ;
Rew, JS ;
Choi, SK ;
Bom, HS ;
Park, CS ;
Kim, SJ .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 2002, 35 (01) :35-42
[28]   Relationship between LSD1 expression and E-cadherin expression in prostate cancer [J].
Wang, Min ;
Liu, Xiuheng ;
Jiang, Guanjun ;
Chen, Hui ;
Guo, Jia ;
Weng, Xiaodong .
INTERNATIONAL UROLOGY AND NEPHROLOGY, 2015, 47 (03) :485-490
[29]   E-cadherin expression correlates with tumor differentiation in colorectal cancer [J].
Karatzas, G ;
Karayiannakis, AJ ;
Syrigos, KN ;
Chatzigianni, E ;
Papanikolaou, S ;
Riza, F ;
Papanikolaou, D .
HEPATO-GASTROENTEROLOGY, 1999, 46 (25) :232-235
[30]   Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer [J].
Hu, Yue ;
Dai, Mingrui ;
Zheng, Yayuan ;
Wu, Jiaxin ;
Yu, Bin ;
Zhang, Haihong ;
Kong, Wei ;
Wu, Hui ;
Yu, Xianghui .
CLINICAL EPIGENETICS, 2018, 10
12345