Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer

被引：11

作者：

Vermani, Litika ^{[1
]}

Kumar, Rajeev ^{[2
]}

Kannan, Rengaswamy R. ^{[2
]}

Deka, Monoj K. ^{[3
]}

Talukdar, Anuradha ^{[2
]}

Kumar, Nachimuthu S. ^{[1
]}

机构：

[1] Mizoram Univ, Biotechnol, Aizawl 796004, Mizoram, India

[2] Cachar Canc Hosp & Res Ctr, Res, Silchar 788015, India

[3] Silchar Med Coll & Hosp, Silchar 788015, India

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 14期

关键词：

ALDH1; cancer stem cell; E-cadherin; epithelial mesenchymal transition; twist; Vimentin; young colorectal cancer; EPITHELIAL-MESENCHYMAL TRANSITION; LYMPH-NODE METASTASIS; PROGNOSTIC MARKER; STEM-CELLS; EMT; YOUNG; OVEREXPRESSION; SIGNATURE; EPCAM;

D O I：

10.2217/bmm-2020-0206

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim:To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age.Materials & methods:Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples.Results:ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001).Conclusion:High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer.

引用

页码：1371 / 1382

页数：12

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