Expression pattern of ALDH1, E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer

被引：11

作者：

Vermani, Litika ^{[1
]}

Kumar, Rajeev ^{[2
]}

Kannan, Rengaswamy R. ^{[2
]}

Deka, Monoj K. ^{[3
]}

Talukdar, Anuradha ^{[2
]}

Kumar, Nachimuthu S. ^{[1
]}

机构：

[1] Mizoram Univ, Biotechnol, Aizawl 796004, Mizoram, India

[2] Cachar Canc Hosp & Res Ctr, Res, Silchar 788015, India

[3] Silchar Med Coll & Hosp, Silchar 788015, India

来源：

BIOMARKERS IN MEDICINE | 2020年 / 14卷 / 14期

关键词：

ALDH1; cancer stem cell; E-cadherin; epithelial mesenchymal transition; twist; Vimentin; young colorectal cancer; EPITHELIAL-MESENCHYMAL TRANSITION; LYMPH-NODE METASTASIS; PROGNOSTIC MARKER; STEM-CELLS; EMT; YOUNG; OVEREXPRESSION; SIGNATURE; EPCAM;

D O I：

10.2217/bmm-2020-0206

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Aim:To evaluate the expression pattern of ALDH1 (aldehyde dehydrogenase 1), E-cadherin, Vimentin and Twist in early and late onset sporadic colorectal cancer (CRC) and to study association of their expression with the occurrence of CRC at a young age.Materials & methods:Immunohistochemistry of ALDH1, E-cadherin, Vimentin and Twist was performed on 103 pretreated CRC biopsy samples.Results:ALDH1 expression was found to have strong correlation with early onset CRC (p < 0.0001).Conclusion:High ALDH1 expression correlates with the early onset of CRC. ALDH1 over-expression correlates with poor overall survival in colon cancer.

引用

页码：1371 / 1382

页数：12

共 51 条

[1]

[Anonymous], 2016, Sci. Rep. UK

[2] An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors [J].

Ben-Porath, Ittai ;

Thomson, Matthew W. ;

Carey, Vincent J. ;

Ge, Ruping ;

Bell, George W. ;

Regev, Aviv ;

Weinberg, Robert A. .

NATURE GENETICS, 2008, 40 (05) :499-507

[3] Biomarker targeting of colorectal cancer stem cells [J].

Caparosa, Ellen M. ;

Stem, Jonathan ;

Snook, Adam E. ;

Waldman, Scott A. .

BIOMARKERS IN MEDICINE, 2019, 13 (11) :891-894

[4] The burden of cancers and their variations across the states of India: the Global Burden of Disease Study 1990-2016 [J].

Dhillon, Preet K. ;

Mathur, Prashant ;

Nandakumar, A. ;

Fitzmaurice, Christina ;

Kumar, G. Anil ;

Mehrotra, Ravi ;

Shukla, D. K. ;

Rath, G. K. ;

Gupta, Prakash C. ;

Swaminathan, Rajaraman ;

Thakur, J. S. ;

Dey, Subhojit ;

Allen, Christine ;

Badwe, R. A. ;

Dikshit, Rajesh ;

Dhaliwal, R. S. ;

Kaur, Tanvir ;

Kataki, Amal C. ;

Visvveswara, Rudrapatna N. ;

Gangadharan, P. ;

Dutta, Eliza ;

Furtado, Melissa ;

Varghese, Chris M. ;

Bhardwaj, Deeksha ;

Muraleedharan, Pallavi ;

Odell, Christopher M. ;

Glenn, Scott ;

Bal, Manjit S. ;

Bapsy, P. P. ;

Bennett, James ;

Bodal, Vijay K. ;

Chakma, J. K. ;

Chakravarty, Sekhar ;

Chaturvedi, Meesha ;

Das, Priyanka ;

Deshmane, Vinay ;

Gangane, Nitin ;

Harvey, James ;

Jayalekshmi, P. ;

Jerang, Kaling ;

Johnson, Sarah C. ;

Julka, P. K. ;

Kaushik, Debnath ;

Khamo, Vinotsole ;

Koyande, Shravani ;

Kutz, Michael ;

Langstieh, W. B. ;

Lingegowda, K. B. ;

Mahajan, R. C. ;

Mahanta, Jagadish .

LANCET ONCOLOGY, 2018, 19 (10) :1289-1306

[5]

DORUDI S, 1993, AM J PATHOL, V142, P981

[6] Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy [J].

Dylla, Scott J. ;

Beviglia, Lucia ;

Park, In-Kyung ;

Chartier, Cecile ;

Raval, Janak ;

Ngan, Lucy ;

Pickell, Kellie ;

Aguilar, Jorge ;

Lazetic, Sasha ;

Smith-Berdan, Stephanie ;

Clarke, Michael F. ;

Hoey, Tim ;

Lewicki, John ;

Gurney, Austin L. .

PLOS ONE, 2008, 3 (06)

[7] Overexpression of Snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells [J].

Fan, Fan ;

Samuel, Shaija ;

Evans, Kurt W. ;

Lu, Jia ;

Xia, Ling ;

Zhou, Yunfei ;

Sceusi, Eric ;

Tozzi, Federico ;

Ye, Xiang-Cang ;

Mani, Sendurai A. ;

Ellis, Lee M. .

CANCER MEDICINE, 2012, 1 (01) :5-16

[8]

Farace Cristiano, 2020, Oncotarget, V11, P116, DOI 10.18632/oncotarget.27411

[9] ALDH1 as a prognostic marker for lymph node metastasis in OSCC [J].

Goetz, Carolin ;

Bissinger, Oliver ;

Nobis, Christopher ;

Wolff, Klaus Dietrich ;

Drecoll, Enken ;

Kolk, Andreas .

BIOMEDICAL REPORTS, 2018, 9 (04) :284-290

[10] TWIST1 Is Expressed in Colorectal Carcinomas and Predicts Patient Survival [J].

Gomez, Irene ;

Pena, Cristina ;

Herrera, Mercedes ;

Munoz, Concepcion ;

Jesus Larriba, Maria ;

Garcia, Vanesa ;

Dominguez, Gemma ;

Silva, Javier ;

Rodriguez, Rufo ;

Garcia de Herreros, Antonio ;

Bonilla, Felix ;

Garcia, Jose M. .

PLOS ONE, 2011, 6 (03)

← 1 2 3 4 5 6 →