DNA-binding-protein inhomogeneity in E. coli modeled as biphasic facilitated diffusion

被引：10

作者：

Kuhlman, Thomas E. ^{[1
,2
]}

Cox, Edward C. ^{[3
]}

机构：

[1] Univ Illinois, Dept Phys, Ctr Phys Living Cells, Urbana, IL 61801 USA

[2] Univ Illinois, Ctr Biophys & Computat Biol, Urbana, IL 61801 USA

[3] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA

来源：

PHYSICAL REVIEW E | 2013年 / 88卷 / 02期

基金：

美国国家卫生研究院;

关键词：

REPRESSOR-OPERATOR INTERACTION; ESCHERICHIA-COLI; TRANSCRIPTIONAL REGULATION; DRIVEN MECHANISMS; NUCLEIC-ACIDS; LAC OPERON; ORGANIZATION; CHROMOSOME; TRANSLOCATION; DYNAMICS;

D O I：

10.1103/PhysRevE.88.022701

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

We have recently shown that nonspecifically bound lac repressors are spatially inhomogeneous in E. coli cells and depends upon the location of its encoding gene and the DNA compaction state [Kuhlman and Cox, Mol. Syst. Biol. 8, 610 (2012)]. Here we model this inhomogeneity as a consequence of diffusion within and exchange between two distinct intracellular phases: the condensed chromosomal DNA and an extrachromosomal compartment, the cytoplasm. We discuss the consequences of this model for the target search process.

引用

页数：6

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