Microbiome in lung explants of idiopathic pulmonary fibrosis: a case-control study in patients with end-stage fibrosis

被引：28

作者：

Kitsios, Georgios D. ^{[1
,2
]}

Rojas, Mauricio ^{[1
]}

Kass, Daniel J. ^{[1
]}

Fitch, Adam ^{[1
,2
]}

Sembrat, John C. ^{[1
]}

Qin, Shulin ^{[1
,2
]}

Veraldi, Kristen L. ^{[1
]}

Gibson, Kevin F. ^{[1
]}

Lindell, Kathleen ^{[1
]}

Pilewski, Joseph M. ^{[1
]}

Methe, Barbara ^{[1
,2
]}

Li, Kelvin ^{[2
]}

McDyer, John ^{[1
]}

McVerry, Bryan J. ^{[1
,2
]}

Morris, Alison ^{[1
,2
,3
]}

机构：

[1] Univ Pittsburgh, Med Ctr, Div Pulm Allergy & Crit Care Med, Dept Med, Pittsburgh, PA USA

[2] Univ Pittsburgh, Dept Med, Ctr Med & Microbiome, Pittsburgh, PA USA

[3] Univ Pittsburgh, Sch Med, Dept Immunol, Pittsburgh, PA USA

来源：

THORAX | 2018年 / 73卷 / 05期

基金：

美国国家卫生研究院;

关键词：

PROGRESSION;

D O I：

10.1136/thoraxjnl-2017-210537

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The microbiome has been proposed to play a role in the progression of idiopathic pulmonary fibrosis (IPF) based on bronchoalveolar lavage analyses, but the microbiome of lung tissue in IPF has not been explored. In a case-control study of lung explants analysed by 16S rRNA gene sequencing, we could not reliably detect bacterial DNA in basilar tissue samples from patients with either chronic or acute exacerbations of IPF, in contrast to control candidate-donor lungs or cystic fibrosis explants. Thus, our data do not indicate microbiome alterations in regions of IPF lung with advanced fibrosis.

引用

页码：481 / 484

页数：4

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