From obesity to cancer: a review on proposed mechanisms

被引:85
作者
Tahergorabi, Zoya [1 ]
Khazaei, Majid [2 ]
Moodi, Mitra [3 ]
Chamani, Elham [4 ]
机构
[1] Birjand Univ Med Sci, Dept Physiol, Cellular & Mol Res Ctr, Birjand, Iran
[2] Mashhad Univ Med Sci, Dept Physiol, Mashhad, Iran
[3] Birjand Univ Med Sci, Social Determinants Hlth Res Ctr, Birjand, Iran
[4] Birjand Univ Med Sci, Dept Biochem, Cellular & Mol Res Ctr, Gaffari St, Birjand, Iran
关键词
adipose tissue; cancer; mechanism; obesity; TUMOR-NECROSIS-FACTOR; SILTUXIMAB CNTO 328; ADIPOSE-TISSUE; TGF-BETA; PROSTATE-CANCER; GROWTH-FACTOR; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; METABOLIC SYNDROME; MULTIPLE-MYELOMA;
D O I
10.1002/cbf.3229
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nowadays, obesity is considered as a serious and growing global health problem. It is documented that the overweight and obesity are major risk factors for a series of noncommunicable diseases, and in recent years, the obesity-cancer link has received much attention. Numerous epidemiological studies have shown that obesity is associated with increased risk of several cancer types, including colon, breast, endometrium, liver, kidney, esophagus, gastric, pancreatic, gallbladder, and leukemia, and can also lead to poorer treatment. We review here the epidemiological and experimental evidences for the association between obesity and cancer. Specifically, we discuss potential mechanisms focusing how dysfunctional angiogenesis, chronic inflammation, interaction of proinflammatory cytokines, endocrine hormones, and adipokines including leptin, adiponectin insulin, growth factors, estrogen, and progesterone and strikingly, cell metabolism alteration in obesity participate in tumor development and progression, resistance to chemotherapy, and targeted therapies such as antiangiogenic and immune therapies.
引用
收藏
页码:533 / 545
页数:13
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