Auto-redox reaction:: Tin(II) chloride-mediated one-step reductive cyclization leading to the synthesis of novel biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity

被引：71
作者：
Roy, AD [1 ]
Subramanian, A [1 ]
Roy, R [1 ]
机构：
[1] Cent Drug Res Inst, Div SAIF, Lucknow 226001, Uttar Pradesh, India
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 01期
关键词：
D O I：
10.1021/jo0518912
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A tin(II) chloride-mediated short, efficient, and practical regioselective synthesis of biheterocyclic 5,6-dihydro-quinazolino[4,3-b]quinazolin-8-ones with three-point diversity is reported. A one-step reductive transformation of 2-(2-nitrophenyl)-3H-quinazolin-4-one in various alcohols furnished the desired tetracyclic product in good yields with high purity.
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收藏
页码：382 / 385
页数：4
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