Electrical Stimulation of Vascular Autonomic Nerves: Effects on Heart Rate, Blood Pressure, and Arrhythmias

被引:10
|
作者
Sun, Jian [1 ]
Scherlag, Benjamin J. [2 ]
He, Bo [2 ]
Shen, Xiaohua [2 ]
Gao, Mei [2 ]
Zhang, Ling [3 ]
Li, Yigang [1 ]
Po, Sunny S. [2 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Med, Dept Cardiol, Xinhua Hosp, Shanghai 200030, Peoples R China
[2] Univ Oklahoma HSC, Heart Rhythm Inst, Oklahoma City, OK USA
[3] Xinjiang Med Univ, Affiliated Hosp 1, Dept Cardiol, Xinjiang, Peoples R China
来源
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY | 2015年 / 38卷 / 07期
关键词
autonomic nerve stimulation; renal artery; pulmonary artery; heart rate; blood pressure; arrhythmia; RENAL SYMPATHETIC DENERVATION; OUTFLOW TRACT TACHYCARDIA; PULMONARY VEIN ISOLATION; ATRIAL-FIBRILLATION; ARTERY DENERVATION; HYPERTENSION; BARORECEPTORS; INNERVATION; FIBERS; TRIAL;
D O I
10.1111/pace.12603
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundRecent clinical studies have shown conflicting results of the efficacy of renal sympathetic denervation (RSD) to mitigate hypertension. In this study, we compared electrical stimulation (ES) of autonomic nerves on the surface of the left pulmonary artery (LPA) and renal arteries (RAs) on heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP), and cardiac arrhythmias. MethodsIn 16 pentobarbital anesthetized dogs, standard electrocardiography leads and blood pressure (BP) were continuously recorded. After a left thoracotomy, a circumferential multielectrode catheter was secured around the LPA. Atrial pacing was coupled to the ES applied around the LPA during the QRS complex to avoid ventricular excitation. Flank incisions allowed retroperitoneal expose of the RAs and the aortico-renal ganglia (ARG). HR and SBP/DBP were determined at baseline (BL) and during ES of LPA, RA, or ARG. ResultsDuring ES applied to the LPA, HR was unchanged compared to BL values. In four of six animals, ventricular tachyarrhythmias were induced by ES. SBP increased significantly (BL vs ES, 12917 mm Hg vs 163 +/- 21 mm Hg, P0.05). ES applied to the RAs and ARG did not affect the HR, but significantly increased SBP/DBP (baseline: 134 +/- 24/96 +/- 18 mm Hg; RAs stimulation: 157 +/- 26/114 +/- 18 mm Hg; ARG stimulation: 207 +/- 44/147 +/- 26 mm Hg, P<0.05). ConclusionES of vascular autonomic nerves on LPA, RAs, and ARG significantly increased BP but without effects on HR. ES of ARG induced substantially greater hypertensive responses than ES of RAs, implying that ES of ARG may serve as a biomarker or ablation targets for RSD.
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页码:825 / 830
页数:6
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