Higher Red Blood Cell Distribution Width Is an Adverse Prognostic Factor in Chronic-phase Chronic Myeloid Leukemia Patients Treated with Tyrosine Kinase Inhibitors

被引：5

作者：

Iriyama, Noriyoshi ^{[1
]}

Hatta, Yoshihiro ^{[1
]}

Kobayashi, Sumiko ^{[1
]}

Uchino, Yoshihito ^{[1
]}

Miura, Katsuhiro ^{[1
]}

Kurita, Daisuke ^{[1
]}

Kodaira, Hitomi ^{[1
]}

Takahashi, Hiromichi ^{[1
]}

Iizuka, Yoshikazu ^{[1
]}

Inoue, Mitsuru ^{[2
]}

Takei, Masami ^{[1
]}

机构：

[1] Nihon Univ, Sch Med, Dept Med, Div Hematol & Rheumatol,Itabashi Ku, Tokyo 1738610, Japan

[2] Nihon Univ, Sch Med, Dept Clin Lab, Itabashi Ku, Tokyo 1738610, Japan

来源：

ANTICANCER RESEARCH | 2015年 / 35卷 / 10期

关键词：

Red blood cell distribution width; chronic myeloid leukemia; prognosis; EUTOS SCORE; EUROPEAN TREATMENT; TREATMENT RESPONSE; IMATINIB; RECOMMENDATIONS; DASATINIB; OUTCOMES; NILOTINIB;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The significance of red blood cell distribution width (RDW) was evaluated in patients with chronic myeloid leukemia (CML) in the chronic phase (CP). Eighty-four patients with newly-diagnosed CML-CP treated with any tyrosine kinase inhibitor (TKI) were analyzed. Patients were divided into two groups: a low-RDW group (RDW values <= 15%, n=31) and a high-RDW group (RDW values >15%, n=53). The 5-year event-free survival (EFS) and transformation-free survival (TFS) rates differed significantly between the low-and high-RDW groups (100% and 68%, respectively, in EFS, p=0.0071 and 100% and 81%, respectively, in TFS, p=0.039). The stratification by RDW had an impact on overall 5-year survival (100% in the low and 77% in the high RDW groups, p=0.047). We conclude that the RDW has a critical role in risk stratification of CML-CP patients for predicting treatment responses and outcomes.

引用

页码：5473 / 5478

页数：6

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