Does the presence of adenomyosis and lymphovascular space invasion affect lymph node status in patients with endometrioid adenocarcinoma of the endometrium?

被引：29

作者：

Musa, Fernanda ^{[1
]}

Frey, Melissa K. ^{[3
]}

Im, H. Beatrice ^{[5
]}

Chekmareva, Marina ^{[6
]}

Ellenson, Lora H. ^{[4
]}

Holcomb, Kevin ^{[2
]}

机构：

[1] New York Univ Langone Med Ctr, Dept Obstet & Gynecol, Div Gynecol Oncol, New York, NY USA

[2] New York Presbyterian Hosp, Weill Cornell Med Coll, Div Gynecol Oncol, New York, NY USA

[3] New York Presbyterian Hosp, Weill Cornell Med Coll, Dept Obstet & Gynecol, New York, NY USA

[4] New York Presbyterian Hosp, Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY USA

[5] New York Presbyterian Healthcare Syst, New York Downtown Hosp, Dept Obstet & Gynecol, New York, NY USA

[6] Robert Wood Johnson Univ Hosp, Dept Pathol & Lab Med, New Brunswick, NJ USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2012年 / 207卷 / 05期

关键词：

adenomyosis; endometrial cancer; MYOMETRIAL INVASION; UTERINE ADENOMYOSIS; RISK-FACTOR; CARCINOMA; INVOLVEMENT; EXPRESSION; DISEASE;

D O I：

10.1016/j.ajog.2012.06.051

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: We sought to determine the prevalence of adenomyosis and assess its effect on lymph node status in endometrioid adenocarcinoma of the endometrium (EAC). STUDY DESIGN: Hysterectomy specimens from a single institution were reviewed for the presence of adenomyosis, lymphovascular space invasion (LVSI), tumor grade, histology, and lymph node status. Standard statistical analysis was used to compare variables. RESULTS: Adenomyosis was present in 42% of total and 66% of malignant hysterectomy specimens (P = .009). Adenomyosis was most commonly associated with EAC histology (P = .023). LVSI was found to be an independent predictor of lymph node metastasis in EAC patients without adenomyosis, but not in those with coexisting adenomyosis (odds ratio, 58.7; P = .03; and odds ratio, 4.98; P = .15; respectively). CONCLUSION: Adenomyosis was associated with a lower risk of lymph node metastasis in EAC patients with LVSI. Further studies are needed to investigate the role of adenomyosis in lymphatic tumor infiltration.

引用

页数：6

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