Preparation, characterization and biological studies of some novel ferrocenyl compounds

被引：16
作者：
Abd-Elzaher, MM
Ali, IAI
机构：
[1] Natl Res Ctr, Dept Inorgan Chem, Cairo, Egypt
[2] Suez Canal Univ, Fac Sci, Dept Chem, Ismailia, Egypt
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2006年 / 20卷 / 02期
关键词：
ferrocene; trichloroacetimidates; ferrocenyl carbohydrates; characterization; biological activity;
D O I：
10.1002/aoc.1016
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Reaction of ferrocene with trichloroacetimidates in the presence of TMSOTf as a catalyst gave a series of novel ferrocenyl compounds, 1-7, in good yield and by a simple method using the Friedel-Crafts reaction. Only monosubstituted ferrocenyl compounds were obtained by flash chromatography at room temperature. Attempts to separate the disubstituted ferrocenyl compounds were unsuccessful, even in the presence of excess (2:1,3: 1 or 4: 1) of trichloroacetimidates. The prepared compounds have been characterized by H-1 NMR, C-13 NMR, IR, UV-vis and mass spectra as well as elemental analysis. The prepared compounds showed medium to good antimicrobial activity against Bacillus subtilis (+ve), Staphylococcus aureus (+ve), Candida albicans (yeast), Escherichia coli (-ve), Salmonella typhi (-ve), Aspergillus niger (fungi) and Fusarium solani (fungi). Copyright (c) 2005 John Wiley & Sons, Ltd.
引用
收藏
页码：107 / 111
页数：5
相关论文
共 44 条
  • [1] Synthesis, characterization and biological studies of ferrocenyl complexes containing thiophene moiety
    Abd-Elzaher, MM
    Hegazy, WH
    Gaafar, AEDM
    [J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2005, 19 (08) : 911 - 916
  • [2] Synthesis, characterization, and antimicrobial activity of cobalt(II), nickel(II), copper(H) and zinc(II) complexes with ferrocenyl Schiff bases containing a phenol moiety
    Abd-Elzaher, MM
    [J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2004, 18 (04) : 149 - 155
  • [3] Protection of hydroxy groups with diphenylmethyl and 9-fluorenyl trichloroacetimidates - Effect on anomeric stereocontrol
    Ali, IAI
    El Ashr, ESH
    Schmidt, RR
    [J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2003, 2003 (21) : 4121 - 4131
  • [4] Development of organometallic (organo-transition metal) pharmaceuticals
    Allardyce, CS
    Dorcier, A
    Scolaro, C
    Dyson, PJ
    [J]. APPLIED ORGANOMETALLIC CHEMISTRY, 2005, 19 (01) : 1 - 10
  • [5] Synthesis of glycodendrimers by modification of poly(propylene imine) dendrimers
    Ashton, PR
    Boyd, SE
    Brown, CL
    Nepogodiev, SA
    Meijer, EW
    Peerlings, HWI
    Stoddart, JF
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 1997, 3 (06) : 974 - 984
  • [6] Ashton PR, 2002, CHEM-EUR J, V8, P673, DOI 10.1002/1521-3765(20020201)8:3<673::AID-CHEM673>3.0.CO
  • [7] 2-D
  • [8] A convergent synthesis of a carbohydrate-containing dendrimer
    Ashton, PR
    Boyd, SE
    Brown, CL
    Jayaraman, N
    Stoddart, JF
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1997, 36 (07): : 732 - 735
  • [9] Synthetic carbohydrate dendrimers .1. A convergent synthesis of carbohydrate-containing dendrimers
    Ashton, PR
    Boyd, SE
    Brown, CL
    Jayaraman, N
    Nepogodiev, SA
    Stoddart, JF
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 1996, 2 (09) : 1115 - 1128
  • [10] BOHM L, 2004, EJC SUPPL, V2, P68
12345