Highly Enantioselective Iridium-Catalyzed Hydrogenation of α,β-Unsaturated Esters

被引：71

作者：

Li, Jia-Qi ^{[1
]}

Quan, Xu ^{[1
]}

Andersson, Pher G. ^{[1
,2
]}

机构：

[1] Uppsala Univ, Dept Biochem & Organ Chem, S-75123 Uppsala, Sweden

[2] Univ KwaZulu Natal, Sch Chem, Durban, South Africa

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2012年 / 18卷 / 34期

基金：

瑞典研究理事会;

关键词：

asymmetric catalysis; chirality; hydrogenation; iridium; a; ss-unsaturated esters; ASYMMETRIC CONJUGATE REDUCTION; PHOSPHINE-OXAZOLINE LIGANDS; ABSOLUTE-CONFIGURATION; TRISUBSTITUTED OLEFINS; PHOSPHORUS LIGANDS; THIAZOLE LIGANDS; CHIRAL LIGANDS; ROCHE ESTER; DERIVATIVES; COMPLEXES;

D O I：

10.1002/chem.201200907

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

a,beta-Unsaturated esters have been employed as substrates in iridium-catalyzed asymmetric hydrogenation. Full conversions and good to excellent enantioselectivities (up to 99?% ee) were obtained for a broad range of substrates with both aromatic- and aliphatic substituents on the prochiral carbon. The hydrogenated products are highly useful as building blocks in the synthesis of a variety of natural products and pharmaceuticals.

引用

页码：10609 / 10616

页数：8

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