Argonaute Proteins: From Structure to Function in Development and Pathological Cell Fate Determination

被引：71

作者：

Muller, Madlen ^{[1
,2
]}

Fazi, Francesco ^{[3
]}

Ciaudo, Constance ^{[1
]}

机构：

[1] Swiss Fed Inst Technol Zurich, Dept Biol, IMHS, Zurich, Switzerland

[2] Univ Zurich, Life Sci Zurich Grad Sch, Mol Life Sci Program, Zurich, Switzerland

[3] Sapienza Univ Rome, Fdn Cenci Bolognetti, Dept Anat Histol Forens & Orthoped Sci, Sect Histol & Med Embryol,Lab Affiliated Inst Pas, Rome, Italy

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2020年 / 7卷

基金：

瑞士国家科学基金会;

关键词：

argonaute proteins; expression; structure; posttranslational modifications; development; cancer; EMBRYONIC STEM-CELLS; CRYSTAL-STRUCTURE; TRANSLATIONAL REPRESSION; RNA INTERFERENCE; GENE-EXPRESSION; GUIDE RNA; MICRORNA; PHOSPHORYLATION; RECOGNITION; DICER;

D O I：

10.3389/fcell.2019.00360

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The highly conserved Argonaute protein family members play a central role in the regulation of gene expression networks, orchestrating the establishment and the maintenance of cell identity throughout the entire life cycle, as well as in several human disorders, including cancers. Four functional Argonaute proteins (AGO1-4), with high structure similarity, have been described in humans and mice. Interestingly, only AGO2 is robustly expressed during human and mouse early development, in contrast to the other AGOs. Consequently, AGO2 is indispensable for early developmentin vivoandin vitro. Here, we review the roles of Argonaute proteins during early development by focusing on the interplay between specific domains of the protein and their function. Moreover, we report recent works highlighting the importance of AGO posttranslational modifications in cancer.

引用

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