Geranins A and B, new antiprotozoal A-type proanthocyanidins from Geranium niveum

被引：59
作者：
Calzada, F
Cerda-García-Rojas, CM
Meckes, M
Cedillo-Rivera, R
Bye, R
Mata, R [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Fac Quim, Mexico City 04510, DF, Mexico
[2] Inst Politecn Nacl, Ctr Invest & Estudios Avanzados, Dept Quim, Mexico City 07000, DF, Mexico
[3] IMSS, Ctr Med Nacl Siglo XXI, Hosp Pediat, Mexico City 06725, DF, Mexico
[4] Univ Nacl Autonoma Mexico, Inst Biol, Mexico City 04510, DF, Mexico
来源：
JOURNAL OF NATURAL PRODUCTS | 1999年 / 62卷 / 05期
关键词：
D O I：
10.1021/np980467b
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Bioassay-guided fractionation of the antiprotozoal extract of Geranium niveum led to the isolation of two new A-type proanthocyanidins, epi-afzelechin-(4 beta-->8,2 beta-->O-->7)-afzelechin (1) and epi-catechin-(4 beta-->8,2 beta-->O-->7)-afzelechin (2). Compounds 1 and 2 were given the trivial names of geranins A and B, respectively. In addition, five known compounds, mahuannin B (3), reynoutrin (4), hyperin (5), methyl gallate (6), and 3-beta-caffeoyl-12-oleanen-28-oic acid (7), were obtained. The structures of the new proanthocyanidins were elucidated by spectroscopic and chemical methods as well as CD measurements. Compounds 1, 2, and 4-7 were tested against axenically grown trophozoites of Giardia lamblia and Entamoeba histolytica.
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页码：705 / 709
页数：5
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