Differential gene expression by chrysotile in human bronchial epithelial cells

被引：3

作者：

Seo, Yoo-Na ^{[1
]}

Lee, Yong-Jin ^{[2
,3
]}

Lee, Mi-Young ^{[1
]}

机构：

[1] SoonChunHyang Univ, Dept Med Biotechnol, Asan, Chungnam, South Korea

[2] SoonChunHyung Univ, Dept Med, Cheonan, Chungnam, South Korea

[3] SoonChunHyung Environm Hlth Ctr Asbestos Related, Cheonan, Chungnam, South Korea

来源：

ANIMAL CELLS AND SYSTEMS | 2012年 / 16卷 / 02期

关键词：

chrysotile; human bronchial epithelial cells; differential gene expression; PLEURAL MESOTHELIAL CELLS; ASBESTOS; ACTIVATION; EXPOSURE; RAT; PROFILES; PROTEINS; KINASES; STRESS; FAMILY;

D O I：

10.1080/19768354.2011.628696

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Asbestos exposure has been known to contribute to several lung diseases named asbestosis, malignant mesothelioma and lung cancer, but the disease-related molecular and cellular mechanisms are still largely unknown. To examine the effects of asbestos exposure in human bronchial epithelial cells at gene level, the global gene expression profile was analyzed following chrysotile treatment. The microarray results revealed differential gene expression in response to chrysotile treatment. The genes up-and down-regulated by chrysotile were mainly involved in processes including metabolism, signal transduction, transport, development, transcription, immune response, and other functions. The differential gene expression profiles could provide clues that might be used to understand the pathological mechanisms and therapeutic targets involved in chrysotile-related diseases.

引用

页码：95 / 103

页数：9

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