Analysis of the concerted metalation-deprotonation mechanism in palladium-catalyzed direct arylation across a broad range of aromatic substrates

被引：875

作者：

Gorelsky, Serge I. ^{[1
]}

Lapointe, David ^{[1
]}

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 33期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1021/ja802533u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The concerted metalation-deprotonation mechanism predicts relative reactivity and regioselectivity for a diverse set of arenes spanning the entire spectrum of known palladium-catalyzed direct arylation coupling partners. An analysis following an active strain model provides a more complete portrayal of the important arene/catalyst parameters leading to a successful coupling. The breadth of arenes whose reactivity can be predicted by the CMD mechanism indicates that it may be far more widespread than previously imagined.

引用

页码：10848 / +

页数：3

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