Role of natural antibodies in immune homeostasis: IVIg perspective

被引：68

作者：

Vani, Janakiraman ^{[2
,3
]}

Elluru, Sriramulu ^{[2
,3
,4
]}

Negi, Vir-Singh ^{[5
]}

Lacroix-Desmazes, Sebastien ^{[2
,3
]}

Kazatchkine, Michel D. ^{[2
,3
]}

Bayry, Jagadeesh ^{[2
,3
]}

Kaveri, Srini V. ^{[1
,2
,3
]}

机构：

[1] Univ Paris 06, Ctr Rech Cordeliers,UMR S 872, INSERM,U 872, Equipe 16 Immunopathol & Therapeut Immunointerven, F-75006 Paris, France

[2] Univ Paris 05, UMR S 872, F-75006 Paris, France

[3] INSERM, U872, F-75006 Paris, France

[4] Univ Technol Compiegne, F-60206 Compiegne, France

[5] JIPMER, Dept Med, Pondicherry, India

来源：

AUTOIMMUNITY REVIEWS | 2008年 / 7卷 / 06期

关键词：

intravenous immunoglobulin; natural antibodies; autoimmune diseases; T cells; B cells; dendritic cells;

D O I：

10.1016/j.autrev.2008.04.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Intravenous immunoglobulin (IVIg) has increasingly been used for the treatment of autoimmune and systemic inflammatory diseases in addition to supportive therapy of immunodeficient patients. Although a considerable progress has been made in understanding the mechanisms by which IVIg exerts inummomodulatory functions in these diseases, they remain not fully elucidated. The mode of action of IVIg is complex, involving interference with activation of complement and the cytokine network, modulation of. idiotype network, expression of Fc receptors, and activation, differentiation and effector functions of T and B cells and of antigen-presenting cells such as dendritic cells. The therapeutic effects of IVIg most likely reflect the functions of natural antibodies in maintaining immune homeostasis in healthy individuals. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：440 / 444

页数：5

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