Reciprocal interactions of the intestinal microbiota and immune system

被引:1208
作者
Maynard, Craig L. [1 ]
Elson, Charles O. [2 ]
Hatton, Robin D. [1 ]
Weaver, Casey T. [1 ]
机构
[1] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA
[2] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA
基金
美国国家卫生研究院;
关键词
REGULATORY T-CELLS; INNATE LYMPHOID-CELLS; SEGMENTED FILAMENTOUS BACTERIA; INFLAMMATORY-BOWEL-DISEASE; TOLL-LIKE RECEPTORS; INDUCER-LIKE CELLS; CROHNS-DISEASE; RETINOIC-ACID; DENDRITIC CELLS; GUT MICROBIOTA;
D O I
10.1038/nature11551
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The emergence of the adaptive immune system in vertebrates set the stage for evolution of an advanced symbiotic relationship with the intestinal microbiota. The defining features of specificity and memory that characterize adaptive immunity have afforded vertebrates the mechanisms for efficiently tailoring immune responses to diverse types of microbes, whether to promote mutualism or host defence. These same attributes can put the host at risk of immune-mediated diseases that are increasingly linked to the intestinal microbiota. Understanding how the adaptive immune system copes with the remarkable number and diversity of microbes that colonize the digestive tract, and how the system integrates with more primitive innate immune mechanisms to maintain immune homeostasis, holds considerable promise for new approaches to modulate immune networks to treat and prevent disease.
引用
收藏
页码:231 / 241
页数:11
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