Antiplatelet therapy in cardiovascular disease

被引：33
作者：
Behan, MWH
Storey, RF
机构：
[1] Univ Nottingham Hosp, Div Cardiovasc Med, Nottingham NG7 2UH, England
[2] No Gen Hosp, Cardiovasc Res Grp, Sheffield S5 7AU, S Yorkshire, England
来源：
POSTGRADUATE MEDICAL JOURNAL | 2004年 / 80卷 / 941期
关键词：
D O I：
10.1136/pgmj.2003.007062
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Platelet activation and aggregation are considered to be central to arterial thrombus formation. Antiplatelet therapy is therefore important for both the treatment and prevention of cardiovascular disease. Aspirin, the most widely used antiplatelet agent, inhibits platelet cyclo-oxygenase and the conversion of arachidonic acid to the potent platelet agonist thromboxane A(2) but does not prevent platelet activation occurring via various signalling pathways that are independent of thromboxane A(2) release. Therefore a number of other compounds have been developed to complement aspirin's beneficial effect. These include the thienopyridines (clopidogrel and ticlopidine), dipyridamole, and the alpha(IIb)beta(3) (glycoprotein IIb/IIIa) receptor inhibitors.
引用
收藏
页码：155 / 164
页数：10
相关论文
共 67 条
[51]  
SINGER R, 1945, ARCH OTOLARYNGOL, V42, P19
[52]   Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention - A randomized controlled trial [J].
Steinhubl, SR ;
Berger, PB ;
Mann, JT ;
Fry, ETA ;
DeLago, A ;
Wilmer, C ;
Topol, EJ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (19) :2411-2420
[53]   Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction. [J].
Stone, GW ;
Grines, CL ;
Cox, DA ;
Garcia, E ;
Tcheng, JE ;
Griffin, JJ ;
Guagliumi, G ;
Stuckey, T ;
Turco, M ;
Carroll, JD ;
Rutherford, BD ;
Lansky, AJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (13) :957-966
[54]   Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease [J].
Storey, RF ;
Wilcox, RG ;
Heptinstall, S .
PLATELETS, 2002, 13 (07) :407-413
[55]  
Storey RF, 2002, THROMB HAEMOSTASIS, V88, P488
[56]  
Tcheng JE, 1997, LANCET, V349, P1422
[57]   ASPIRIN, HEPARIN, OR BOTH TO TREAT ACUTE UNSTABLE ANGINA [J].
THEROUX, P ;
OUIMET, H ;
MCCANS, J ;
LATOUR, JG ;
JOLY, P ;
LEVY, G ;
PELLETIER, E ;
JUNEAU, M ;
STASIAK, J ;
DEGUISE, P ;
PELLETIER, GB ;
RINZLER, D ;
WATERS, DD .
NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (17) :1105-1111
[58]  
Topol CE, 2000, LANCET, V355, P337
[59]  
Topol E, 1998, NEW ENGL J MED, V339, P436
[60]  
Topol E, 1998, CIRCULATION, V97, P2386
1234567