ROS sets the stage for macrophage differentiation

被引：109

作者：

Covarrubias, Anthony ^{[1
]}

Byles, Vanessa ^{[1
]}

Horng, Tiffany ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA 02115 USA

来源：

CELL RESEARCH | 2013年 / 23卷 / 08期

关键词：

TUMOR-ASSOCIATED MACROPHAGES; CANCER; INFLAMMATION;

D O I：

10.1038/cr.2013.88

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

While M1 macrophages are highly pro-inflammatory and microbicidal, M2 macrophages and the related tumor associated macrophages (TAMs) regulate tissue remodeling and angiogenesis and can display immunomodulatory activity. In July issue of Cell Research, Zhang et al. show that ROS production, critical for the activation and functions of M1 macrophages, is necessary for the differentiation of M2 macrophages and TAMs, and that antioxidant therapy blocks TAM differentiation and tumorigenesis in mouse models of cancer.

引用

页码：984 / 985

页数：2

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