Loading of polymer nanocarriers: Factors, mechanisms and applications

被引：160

作者：

Kowalczuk, Agnieszka ^{[1
]}

Trzcinska, Roza ^{[1
]}

Trzebicka, Barbara ^{[1
]}

Mueller, Axel H. E. ^{[2
]}

Dworak, Andrzej ^{[1
]}

Tsvetanov, Christo B. ^{[3
]}

机构：

[1] Polish Acad Sci, Ctr Polymer & Carbon Mat, PL-41819 Zabrze, Poland

[2] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55099 Mainz, Germany

[3] Bulgarian Acad Sci, Inst Polymers, BU-1113 Sofia, Bulgaria

来源：

PROGRESS IN POLYMER SCIENCE | 2014年 / 39卷 / 01期

关键词：

Polymeric nanoparticles; Loading; Mechanism; Nanocarriers; BLOCK-COPOLYMER MICELLES; MESOPOROUS SILICA NANOPARTICLES; IRON-OXIDE NANOPARTICLES; POLYION COMPLEX MICELLES; MICROCAPSULES ASSEMBLED STEPWISE; PH-RESPONSIVE NANOGELS; HEAT-INDUCED SHRINKAGE; CORE-SHELL PARTICLES; IN-VITRO RELEASE; DRUG-DELIVERY;

D O I：

10.1016/j.progpolymsci.2013.10.004

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The progress in synthetic polymer chemistry has allowed the precise design of hybrid and multifunctional colloidal particles, which differ in type, size and shape, thus enhancing their possible applications as target-oriented carriers of low and high molar mass active species. This survey discusses the basic principles and factors, associated with the process of loading of polymeric nanoparticles. For the purpose of this review, the polymeric nano-carriers are divided into five most studied types: micelles, nanogels, capsules (incl. vesicles), dendrimers, and hybrid nanoparticles with porous cores. Factors influencing the loading are described and their importance discussed. An important trend is the synthesis of multicompartment carriers for the encapsulation of different types of therapeutics. Special attention is focused on the loading of biomacromolecules. (C) 2013 Published by Elsevier Ltd.

引用

页码：43 / 86

页数：44

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