Comprehensive evaluation of antioxidant activity: A chemometric approach using principal component analysis

被引：10
作者：
Casoni, Dorina [1 ]
Sarbu, Costel [1 ]
机构：
[1] Univ Babes Bolyai, Fac Chem & Chem Engn, Dept Chem, RO-400028 Cluj Napoca, Romania
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2014年 / 118卷
关键词：
Radical scavenging activity; Biogenic amine related drugs; UV-Vis spectra; PCA profiles; Antioxidant activity; PHENOLIC-COMPOUNDS; SCAVENGING ACTIVITY; OXIDATIVE STABILITY; CLASSIFICATION; PREDICTION; ABILITY; DRUGS;
D O I：
10.1016/j.saa.2013.08.094
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
A novel chemometric approach is described for evaluating the radical scavenging activity of biogenic amine related compounds by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH center dot) procedure and principal component analysis (PCA) tool. By a comprehensive chemometric investigation of variations in the radical scavenging profiles provided by the full-range UV-Vis spectra for different test duration and different relative concentrations (different molar ratio - [AH]/[DPPH center dot]) of the investigated compounds, new antioxidant activity evaluation parameters were proposed. The new proposed parameters (PC1, mPC1, maxPC1) are in good agreement with the reference DPPH. results (% RSA and IC50 derived from the reference DPPH. test), obtained for the investigated amines and reference antioxidants. Much more, the PCA profiles are better patterns for the comprehensive characterization of radical scavenging activity of compounds, allowing visualization of complex information by a simple graphical representation and underlying the (dis)similarity of compounds related both to the reaction kinetics and compounds concentration. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：343 / 348
页数：6
相关论文
共 42 条
  • [1] Antolovich M, 2002, ANALYST, V127, P183, DOI 10.1039/b009171p
  • [2] Characterization of food antioxidants, illustrated using commercial garlic and ginger preparations
    Aruoma, OI
    Spencer, JPE
    Warren, D
    Jenner, P
    Butler, J
    Halliwell, B
    [J]. FOOD CHEMISTRY, 1997, 60 (02) : 149 - 156
  • [3] Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling
    Baker, Jillian G.
    Hill, Stephen J.
    Summers, Roger J.
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 2011, 32 (04) : 227 - 234
  • [4] The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay
    Benzie, IFF
    Strain, JJ
    [J]. ANALYTICAL BIOCHEMISTRY, 1996, 239 (01) : 70 - 76
  • [5] Use of 2,2′-Azobis(2-amidinopropane) dihydrochloride as a reagent tool for evaluation of oxidative stability of drugs
    Betigeri, S
    Thakur, A
    Raghavan, K
    [J]. PHARMACEUTICAL RESEARCH, 2005, 22 (02) : 310 - 317
  • [6] Application of artificial neural networks to the prediction of the antioxidant activity of essential oils in two experimental in vitro models
    Cabrera, Alvaro Cortes
    Prieto, Jose M.
    [J]. FOOD CHEMISTRY, 2010, 118 (01) : 141 - 146
  • [7] Classification of eight pomegranate juices based on antioxidant capacity measured by four methods
    Cam, Mustafa
    Hisil, Yasar
    Durmaz, Goekhan
    [J]. FOOD CHEMISTRY, 2009, 112 (03) : 721 - 726
  • [8] Comparisons of different regressions tools in measurement of antioxidant activity in green tea using near infrared spectroscopy
    Chen, Quansheng
    Guo, Zhiming
    Zhao, Jiewen
    Ouyang, Qin
    [J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2012, 60 : 92 - 97
  • [9] Chu YH, 2000, J SCI FOOD AGR, V80, P561, DOI 10.1002/(SICI)1097-0010(200004)80:5<561::AID-JSFA574>3.0.CO
  • [10] 2-#
12345