Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal

被引：55

作者：

Althouse, Benjamin M. ^{[1
,2
,3
]}

Guerbois, Mathilde ^{[4
]}

Cummings, Derek A. T. ^{[5
]}

Diop, Ousmane M. ^{[6
]}

Faye, Ousmane ^{[6
]}

Faye, Abdourahmane ^{[6
]}

Diallo, Diawo ^{[6
]}

Sadio, Bakary Djilocalisse ^{[6
]}

Sow, Abdourahmane ^{[6
]}

Faye, Oumar ^{[6
]}

Sall, Amadou A. ^{[6
]}

Diallo, Mawlouth ^{[6
]}

Benefit, Brenda ^{[7
]}

Simons, Evan ^{[7
]}

Watts, Douglas M. ^{[8
,9
,10
]}

Weaver, Scott C. ^{[11
,12
]}

Hanley, Kathryn A. ^{[3
]}

机构：

[1] Inst Dis Modeling, Bellevue, WA 98005 USA

[2] Univ Washington, Informat Sch, Seattle, WA 98105 USA

[3] New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA

[4] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[5] Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32608 USA

[6] Inst Pasteur, Dakar, Senegal

[7] New Mexico State Univ, Dept Anthropol, Las Cruces, NM 88003 USA

[8] Univ Texas El Paso, Off Res & Sponsored Projects, El Paso, TX 79968 USA

[9] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA

[10] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA

[11] Univ Texas Med Branch, Inst Human Infect, Galveston, TX 77555 USA

[12] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

来源：

NATURE COMMUNICATIONS | 2018年 / 9卷

关键词：

CERCOPITHECUS-AETHIOPS; ERYTHROCEBUS-PATAS; ANTIBODY KINETICS; INFECTION; WILD; TRANSMISSION; RESERVOIRS; PATTERNS; VECTORS; SUSCEPTIBILITY;

D O I：

10.1038/s41467-018-03332-7

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Arboviruses spillover into humans either as a one-step jump from a reservoir host species into humans or as a two-step jump from the reservoir to an amplification host species and thence to humans. Little is known about arbovirus transmission dynamics in reservoir and amplification hosts. Here we elucidate the role of monkeys in the sylvatic, enzootic cycle of chikungunya virus (CHIKV) in the region around Kedougou, Senegal. Over 3 years, 737 monkeys were captured, aged using anthropometry and dentition, and tested for exposure to CHIKV by detection of neutralizing antibodies. Infant monkeys were positive for CHIKV even when the virus was not detected in a concurrent survey of mosquitoes and when population immunity was too high for monkeys alone to support continuous transmission. We conclude that monkeys in this region serve as amplification hosts of CHIKV. Additional efforts are needed to identify other hosts capable of supporting continuous circulation.

引用

页数：10

共 65 条

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