Process Intensification of Tetrazole reaction through tritylation of 5-[4′-(Methyl) Sipheny1-2-Y1] using microreactors

Currently, process intensification research is focused on use of the continuous micro reactor over the batch reactors. The micro reactor process gives continuous product output, effective micro mixing and better yield in small residence time over batch reactors. A continuous flow process has been successfully developed for the tritylation of 5-(4'-methyl-[1,1'-biphenyl]-2-y1)-1H-tetrazole [MBPT] using different microreactors. The reaction was carried out in three different configurations of microreactors. The SSCR-1 mm and 2 mm (Stainless steel capillary coil micro reactors) gives yield of 93.72 and 92.87% for the residence time of 71 s and 324s respectively. Among the three microreactors, Corning AFR afforded effectively higher yield (95.18%) for the residence time of 27 s. Thus, 5-(4'-methyl-[1,1'-biphenyl]-2-y1)-1trity1-1H-tetrazole, a useful intermediate material for some of the pharmaceutical products that can be produced industrially using microreactor. (C) 2016 Elsevier B.V. All rights reserved.