Investigating the Effects of Ibuprofen on the Gene Expression Profile in Hippocampus of Mice Model of Alzheimer's Disease through Bioinformatics Analysis

被引：8

作者：

Zamanian-Azodi, Mona ^{[1
]}

Rezaei-Tavirani, Mostafa ^{[2
]}

Rezaei-Tavirani, Majid ^{[3
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Prote Res Ctr, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Fac Paramed Sci, Prote Res Ctr, Tehran, Iran

[3] Iran Univ Med Sci, Fac Med, Tehran, Iran

来源：

IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH | 2020年 / 19卷 / 02期

关键词：

Non-steroidal anti-inflammatory drugs; Hippocampus; Alzheimer's disease; Transcriptome; Protein-protein interaction network analysis; Penk; MEMORY DEFICITS; ASSOCIATION; CYTOSCAPE; SAFETY;

D O I：

10.22037/ijpr.2019.15485.13125

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Non-steroidal anti-inflammatory drugs (NSAIDs) are identified as effective in many diseases. One of which is neurodegenerative diseases including Alzheimer disease (AD). In this study gross alteration of gene expression in AD mice by ibuprofen treatment is investigated via Protein -protein interaction network (PPI) analysis. Expression profiling of microarray dataset GSE67306 was retrieved from GEO database and analyzed via GEO2R tool. PPI analysis was performed via Cytoscape 3.7.0. and its plug-ins including Network Analyzer, Gene MANIA, and CluePedia. Numbers of 10 central genes including Htr1a, Sstr2, Drd2, Htr1b, Penk, Pomc, Oprm1, Npy, Sst, and Chrm2 were identified as potential biomarkers. However, the role of Penk gene was highlighted. The finding indicates that ibuprofen changes gene expression level of several genes that are involved in AD.

引用

页码：352 / 359

页数：8

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