Cord blood transplantation in aplastic anemia

被引：31
作者：
de Latour, R. Peffault [1 ]
Rocha, V. [2 ]
Socie, G. [1 ]
机构：
[1] Univ Paris 07, Bone Marrow Transplant Unit, Hop St Louis, APHP, F-75010 Paris, France
[2] Univ Paris 07, Eurocord, Hop St Louis, APHP, F-75010 Paris, France
来源：
BONE MARROW TRANSPLANTATION | 2013年 / 48卷 / 02期
关键词：
cord blood; transplantation; aplastic anemia; STEM-CELL TRANSPLANTATION; MARROW-TRANSPLANTATION; FAILURE;
D O I：
10.1038/bmt.2012.252
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
For patients with inherited BM failure (BMF) or those with acquired BMF who fail immunosuppressive therapy and who lack a suitable alternative donor, the prognosis remains poor. Umbilical cord blood transplantation has extended the availability of hematopoietic stem cell transplantation in the absence of a suitable donor. A recent EBMT study confirmed the feasibility of this treatment and highlighted the fundamental role of the TNC dose (>3.9 x 10(7)/kg TNC/kg) on both engraftment and OS using cord blood as stem cell source in severe aplastic anemia. However, this procedure is still experimental and should be evaluated only through prospective clinical trials. Bone Marrow Transplantation (2013) 48, 201-202; doi:10.1038/bmt.2012.252; published online 7 January 2013
引用
收藏
页码：201 / 202
页数：2
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