Probing multifractality in tissue refractive index: prospects for precancer detection

被引：36

作者：

Das, Nandan ^{[1
]}

Chatterjee, Subhasri ^{[1
]}

Soni, Jalpa ^{[1
]}

Jagtap, Jaidip ^{[2
]}

Pradhan, Asima ^{[2
]}

Sengupta, Tapas K. ^{[1
]}

Panigrahi, Prasanta K. ^{[1
]}

Vitkin, I. Alex ^{[3
]}

Ghosh, Nirmalya ^{[1
]}

机构：

[1] IISER Kolkata, Nadia 741252, W Bengal, India

[2] IIT, Dept Phys, Kanpur 208016, Uttar Pradesh, India

[3] Univ Toronto, Ontario Canc Inst, Dept Med Biophys, Toronto, ON M5G 2M9, Canada

来源：

OPTICS LETTERS | 2013年 / 38卷 / 02期

关键词：

BIOLOGICAL TISSUE; LIGHT-SCATTERING; CELLS;

D O I：

10.1364/OL.38.000211

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Multiresolution analysis on the spatial refractive index inhomogeneities in the epithelium and connective tissue regions of a human cervix reveals a clear signature of multifractality. Importantly, the derived multifractal parameters, namely, the generalized Hurst exponent and the width of the singularity spectrum, derived via multifractal detrended fluctuation analysis, shows interesting differences between tissues having different grades of precancers. The refractive-index fluctuations are found to be more anticorrelated, and the strength of multifractality is observed to be considerably stronger in the higher grades of precancers. These observations on the multifractal nature of tissue refractive-index variations may prove to be valuable for developing light-scattering approaches for noninvasive diagnosis of precancer and early-stage cancer. (C) 2013 Optical Society of America

引用

页码：211 / 213

页数：3

共 10 条

[1] Microscopic Imaging and Spectroscopy with Scattered Light [J].