Transforming growth factor-β signalling in brain disorders

被引：105
|
作者：
Vivien, D [1 ]
Ali, C [1 ]
机构：
[1] Univ Caen, Ctr CYCERON, INSERM, F-14074 Caen, France
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2006年 / 17卷 / 1-2期
关键词：
transforming growth factor-beta; neuroprotection; ischemic stroke; Alzheimer's disease;
D O I：
10.1016/j.cytogfr.2005.09.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transforming growth factor-beta (TGF-beta) has been characterized as an injury-related factor, based on the observation that it is strongly upregulated in many acute or chronic central nervous system disorders. TGF-beta is generally thought to be neuroprotective and several mechanisms have been proposed to explain this beneficial action. For instance, TGF-beta protects neurons against the potentiating effect of tissue-type plasminogen activator on NMDA receptor-mediated excitotoxicity, by up-regulating type-1 plasminogen activator inhibitor expression in astrocytes. TGF-beta has also anti-apoptotic properties, through a recruitment of a mitogen-activated protein kinase pathway and a concomitant activation of anti-apoptotic members of the Bcl-2 family. These multiple mechanisms might reflect the pleiotropic nature of TGF-beta, reinforcing the potential therapeutic value of this cytokine in several central nervous system disorders. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：121 / 128
页数：8
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