Lipase-Catalyzed Stereoselective Cross-Aldol Reaction Promoted by Water

被引：50

作者：

Xie, Zong-Bo ^{[1
,2
,3
]}

Wang, Na ^{[1
,2
]}

Zhou, Long-Hua ^{[1
,2
]}

Wan, Fang ^{[1
,2
]}

He, Ting ^{[1
,2
]}

Le, Zhang-Gao ^{[3
]}

Yu, Xiao-Qi ^{[1
,2
]}

机构：

[1] Sichuan Univ, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China

[2] Sichuan Univ, State Key Lab Oral Dis, Coll Chem, Chengdu 610064, Peoples R China

[3] E China Inst Technol, Sch Chem Biol & Mat Sci, Fuzhou 344000, Peoples R China

来源：

CHEMCATCHEM | 2013年 / 5卷 / 07期

基金：

中国国家自然科学基金;

关键词：

aldol reaction; asymmetric catalysis; lipases; stereoselectivity; water chemistry; PORCINE PANCREATIC LIPASE; CARBON BOND FORMATION; ORGANIC MEDIA; BIOCATALYTIC PROMISCUITY; MARKOVNIKOV ADDITION; MICHAEL ADDITION; EPOXIDATION; ENZYMES;

D O I：

10.1002/cctc.201200890

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

PPL, lipase from porcine pancreas, is first reported to catalyze direct asymmetric aldol reactions between aromatic aldehydes and cyclic ketones. More importantly, the catalytic activity of PPL was greatly promoted by a small quantity of water at 37 degrees C. A wide range of aromatic aldehydes reacted with cyclic ketones to provide the corresponding aldol products with high yields (up to 99%) and moderate to good stereoselectivity (up to 90%ee and 99:1 dr).

引用

页码：1935 / 1940

页数：6

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