PI3K-AKT pathway polymerase chain reaction (PCR) array analysis of epilepsy induced by type II focal cortical dysplasia

被引：10
作者：
Lin, Y. X. [1 ]
Lin, K. [2 ]
Liu, X. X. [3 ]
Kang, D. Z. [1 ]
Ye, Z. X. [1 ]
Wang, X. F. [4 ]
Zheng, S. F. [1 ]
Yu, L. H. [1 ]
Lin, Z. Y. [1 ]
机构：
[1] Fujian Med Univ, Dept Neurosurg, Affiliated Hosp 1, Fuzhou, Peoples R China
[2] Fujian Prov Hosp, Dept Neurosurg, Fuzhou, Peoples R China
[3] Fujian Med Univ, Affiliated Hosp 1, Ultrasound Dept, Fuzhou, Peoples R China
[4] Fujian Med Univ, Affiliated Hosp 1, Dept Pathol, Fuzhou, Peoples R China
来源：
GENETICS AND MOLECULAR RESEARCH | 2015年 / 14卷 / 03期
关键词：
Cortical dysplasia; Epilepsy; Gene chip; PI3K-AKT signaling pathway; TUBEROUS SCLEROSIS COMPLEX; MAMMALIAN TARGET; SIGNALING PATHWAY; MTOR; ACTIVATION; MALFORMATIONS; RAPAMYCIN; MUTATIONS; IMMUNITY;
D O I：
10.4238/2015.August.21.5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The aims of this study were to observe the differential expression of PI3K-AKT pathway-related genes in seizure-inducing brain lesions in type II focal cortical dysplasia, and to explore the relationship between gene expression and histological changes in dysplastic foci and their epileptogenic mechanism. Typical lesions in brain tissue from three patients with epilepsy induced by type II focal cortical dysplasia were selected for analysis, along with normal brain tissue from two control group individuals. Following quantitative expression analysis using the RT2 Profiler (TM) PI3K-AKT PCR Array, differential expression of the pathway related genes was detected in the focal brain tissue lesions, and gene function queries were performed. Compared with the control group, thirteen related genes appeared to exhibit marked differences in expression in epileptic lesions from patients with type II focal cortical dysplasia; those genes were found to be involved in regulation of cell size, morphology, adhesion, migration, and apoptosis, and in immunity, inflammation, and many other domains. The differential expression of multiple genes in the PI3K-AKT signaling pathway in type II focal cortical dysplasia may be an important molecular mechanism underlying histological changes and recurrent seizures.
引用
收藏
页码：9994 / 10000
页数：7
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