Synthesis and cytotoxicity of pyrrole-amino acid dipeptides containing phosphonyl group

被引：0
作者：
Liu, Ruo-yu [1 ]
Ye, Yong [1 ,2 ]
Yang, Jun-liang [1 ]
Liu, Cun-jiang [1 ]
Zhao, Yu-Fen [1 ,2 ]
机构：
[1] Zhengzhou Univ, Dept Chem, Key Lab Chem Biol & Organ Chem, Zhengzhou 450052, Peoples R China
[2] Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Dept Chem, Beijing 100084, Peoples R China
来源：
JOURNAL OF CHEMICAL RESEARCH | 2008年 / 09期
关键词：
pyrrole-arnino acid dipeptide; nitrogen mustard; biological activity;
D O I：
10.3184/030823408X349961
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of pyrrole-amino acid dipeptide were synthesised by chloroform reaction and coupling reaction using DCC/HOBT as promoting additives. The structure of compound was confirmed by H-1 NMR, P-31 NMR, MS and IR. The biological activity data showed that the dipeptide containing nitrogen mustard group inhibited all four cells that were examined.
引用
收藏
页码：528 / 529
页数：2
相关论文
共 12 条
  • [1] Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids
    Baird, EE
    Dervan, PB
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (26) : 6141 - 6146
  • [2] Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands
    Dickinson, LA
    Gulizia, RJ
    Trauger, JW
    Baird, EE
    Mosier, DE
    Gottesfeld, JM
    Dervan, PB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) : 12890 - 12895
  • [3] Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides
    Dickinson, LA
    Trauger, JW
    Baird, EE
    Ghazal, P
    Dervan, PB
    Gottesfeld, JM
    [J]. BIOCHEMISTRY, 1999, 38 (33) : 10801 - 10807
  • [4] Regulation of gene expression by small molecules
    Gottesfeld, JM
    Neely, L
    Trauger, JW
    Baird, EE
    Dervan, PB
    [J]. NATURE, 1997, 387 (6629) : 202 - 205
  • [5] Structural basis for G•C recognition in the DNA minor groove
    Kielkopf, CL
    Baird, EE
    Dervan, PD
    Rees, DC
    [J]. NATURE STRUCTURAL BIOLOGY, 1998, 5 (02) : 104 - 109
  • [6] A structural basis for recognition of A•T and T•A base pairs in the minor groove of B-DNA
    Kielkopf, CL
    White, S
    Szewczyk, JW
    Turner, JM
    Baird, EE
    Dervan, PB
    Rees, DC
    [J]. SCIENCE, 1998, 282 (5386) : 111 - 115
  • [7] Dipeptide seryl-histidine and related oligopeptides cleave DNA, protein, and a carboxyl ester
    Li, YS
    Zhao, YF
    Hatfield, S
    Wan, R
    Zhu, Q
    Li, XH
    McMills, M
    Ma, Y
    Li, J
    Brown, KL
    He, C
    Liu, F
    Chen, XZ
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2000, 8 (12) : 2675 - 2680
  • [8] NISHIWAKI E, 1988, HETEROCYCLES, V27, P1945
  • [9] Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands
    White, S
    Szewczyk, JW
    Turner, JM
    Baird, EE
    Dervan, PB
    [J]. NATURE, 1998, 391 (6666) : 468 - 471
  • [10] Ye Y, 2006, CHINESE CHEM LETT, V17, P1197
12