Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses

被引：67

作者：

Khankari, Nikhil K. ^{[1
]}

Shu, Xiao-Ou ^{[1
]}

Wen, Wanqing ^{[1
]}

Kraft, Peter ^{[2
]}

Lindstrom, Sara ^{[2
]}

Peters, Ulrike ^{[3
]}

Schildkraut, Joellen ^{[4
]}

Schumacher, Fredrick ^{[5
]}

Bofetta, Paolo ^{[6
,7
]}

Risch, Angela ^{[8
,9
,10
]}

Bickeboeller, Heike ^{[11
]}

Amos, Christopher I. ^{[12
]}

Easton, Douglas ^{[13
]}

Eeles, Rosalind A. ^{[14
,15
]}

Gruber, Stephen B. ^{[16
]}

Haiman, Christopher A. ^{[16
,17
]}

Hunter, David J. ^{[18
]}

Chanock, Stephen J. ^{[19
]}

Pierce, Brandon L. ^{[20
]}

Zheng, Wei ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Div Epidemiol,Dept Med,Vanderbilt Epidemiol Ctr, Nashville, TN 37212 USA

[2] Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA

[3] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA

[4] Duke Canc Inst, Canc Prevent Detect & Control Res Program, Durham, NC USA

[5] Univ Southern Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Prevent Med, Los Angeles, CA USA

[6] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA

[7] Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA

[8] Salzburg Univ, Div Canc Genet Epigenet, Dept Mol Biol, Salzburg, Austria

[9] German Canc Res Ctr, Div Epigen & Canc Risk Factors, Heidelberg, Germany

[10] German Ctr Lung Res DZL, Translat Lung Res Ctr Heidelberg, Heidelberg, Germany

[11] Georg August Univ Gottingen, Univ Med Ctr, Dept Genet Epidemiol, Gottingen, Germany

[12] Dartmouth Coll, Geisel Sch Med, Ctr Genom Med, 1 Med Ctr Dr, Lebanon, NH 03756 USA

[13] Univ Cambridge, Dept Oncol, Ctr Canc Genet Epidemiol, Cambridge, England

[14] Inst Canc Res, London, England

[15] Royal Marsden NHS Fdn Trust, London, England

[16] Univ Southern Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA

[17] Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA

[18] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[19] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[20] Univ Chicago, Dept Publ Hlth Studies, Chicago, IL 60637 USA

来源：

PLOS MEDICINE | 2016年 / 13卷 / 09期

关键词：

BODY-MASS-INDEX; DIFFERENT ANATOMIC SITES; GROWTH-FACTOR (IGF)-I; IGF-BINDING PROTEINS; FOLLOW-UP; PROSPECTIVE COHORT; RECTAL-CANCER; SIZE; WEIGHT; COLON;

D O I：

10.1371/journal.pmed.1002118

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Observational studies examining associations between adult height and risk of colorectal, prostate, and lung cancers have generated mixed results. We conducted meta-analyses using data from prospective cohort studies and further carried out Mendelian randomization analyses, using height-associated genetic variants identified in a genome-wide association study (GWAS), to evaluate the association of adult height with these cancers. Methods and Findings A systematic review of prospective studies was conducted using the PubMed, Embase, and Web of Science databases. Usingmeta-analyses, results obtained from 62 studies were summarized for the association of a 10-cm increase in height with cancer risk. Mendelian randomization analyses were conducted using summary statistics obtained for 423 genetic variants identified froma recent GWAS of adult height and from a cancer genetics consortiumstudy of multiple cancers that included 47,800 cases and 81,353 controls. For a 10-cm increase in height, the summary relative risks derived from themeta-analyses of prospective studies were 1.12 (95% CI 1.10, 1.15), 1.07 (95% CI 1.05, 1.10), and 1.06 (95% CI 1.02, 1.11) for colorectal, prostate, and lung cancers, respectively. Mendelian randomization analyses showed increased risks of colorectal (odds ratio [OR] = 1.58, 95% CI 1.14, 2.18) and lung cancer (OR = 1.10, 95% CI 1.00, 1.22) associated with each 10-cm increase in genetically predicted height. No association was observed for prostate cancer (OR = 1.03, 95% CI 0.92, 1.15). Our meta-analysis was limited to published studies. The sample size for the Mendelian randomization analysis of colorectal cancer was relatively small, thus affecting the precision of the point estimate. Conclusions Our study provides evidence for a potential causal association of adult height with the risk of colorectal and lung cancers and suggests that certain genetic factors and biological pathways affecting adult height may also affect the risk of these cancers.

引用

页数：19

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