Marked preservation of the visual and olfactory pathways in ALS patients in a totally locked-in state

被引：18

作者：

Oyanagi, Kiyomitsu ^{[1
]}

Mochizuki, Yoko ^{[2
,4
]}

Nakayama, Yuki ^{[5
]}

Hayashi, Kentaro ^{[3
]}

Shimizu, Toshio ^{[3
]}

Nagao, Masahiro ^{[3
]}

Hashimoto, Tomoyo ^{[6
]}

Yamazaki, Mineo ^{[7
]}

Matsubara, Shiro ^{[3
]}

Komori, Takashi ^{[2
]}

机构：

[1] Shinshu Univ, Sch Med, Dept Brain Dis Res, Div Neuropathol, Matsumoto, Nagano 3908621, Japan

[2] Tokyo Metropolitan Neurol Hosp, Dept Pathol, Fuchu, Tokyo, Japan

[3] Tokyo Metropolitan Neurol Hosp, Dept Neurol, Fuchu, Tokyo, Japan

[4] Tokyo Metropolitan Kita Med & Rehabil Ctr Disable, Dept Neurol, Kita Ku, Tokyo, Japan

[5] Tokyo Metropolitan Inst Med Sci, Lab Nursing Res Intractable Dis, Setagaya Ku, Tokyo 113, Japan

[6] Univ Occupat & Environm Hlth, Dept Neurol, Yahatanishi Ku, Kitakyushu, Fukuoka 807, Japan

[7] Chiba Hokusoh Hosp, Nippon Med Sch, Dept Neurol, Chiba, Japan

来源：

CLINICAL NEUROPATHOLOGY | 2015年 / 34卷 / 05期

关键词：

amyotrophic lateral sclerosis; totally locked-in state; brain-machine interface; optic pathway; olfactory pathway; AMYOTROPHIC-LATERAL-SCLEROSIS; EVOKED-POTENTIALS; FAMILIAL ALS; MUTATION;

D O I：

10.5414/NP300859

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Materials and methods: The present paper examines the brains and spinal cords in 7 patients with amyotrophic lateral sclerosis (ALS) receiving artificial respirator support in a totally locked-in state (TLS) neuropathologically in order to clarify whether any anatomical structures in the central nervous system are preserved. Results and conclusion: We found that the visual and olfactory pathways, hypothalamus, nucleus basalis of Meynert, and commissura anterior were remarkably well preserved, whereas the somatosensory, auditory, and gustatory pathways in the brain stem and/or spinal cord showed severe deterioration.

引用

页码：267 / 274

页数：8

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