Synthesis of Water Soluble Chitosan-Artemisinin Conjugate

被引：4
作者：
Xiao, Dan [1 ]
Yang, Bo [1 ]
Yang, Xue-Min [1 ]
Yi, Dong [1 ]
Liao, Xia-Li [1 ]
Yang, Jian [1 ]
Gao, Chuan-Zhu [1 ]
机构：
[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Peoples R China
来源：
ASIAN JOURNAL OF CHEMISTRY | 2013年 / 25卷 / 08期
基金：
中国国家自然科学基金;
关键词：
Artemisinin; Chitosan; Conjugate; Water soluble; QINGHAOSU ARTEMISININ; ANTIMALARIAL-DRUG; DIHYDROARTEMISININ; CYTOTOXICITY; DERIVATIVES; ARTESUNATE; DELIVERY;
D O I：
10.14233/ajchem.2013.14360
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The conjugate was prepared through a series of reactions starting from the hydrogenation of artemisinin and then acylation hydrolysis 1 and condensation The solubility of chitosan-artemisinin conjugate was evaluated and compared with a normal commercially available 1 artemisinim The results indicated that the had much higher solubility in comparison with artemisinin. The method reported in this paper provides a good yield of chitosan-artmisinn conjugate, chitosan-artemisinin could be attributed to increasing the bioayailability ! I in atternisiniu delivery,
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页码：4637 / 4639
页数：3
相关论文
共 16 条
  • [1] Chitosan-based hydrogels for controlled, localized drug delivery
    Bhattarai, Narayan
    Gunn, Jonathan
    Zhang, Miqin
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2010, 62 (01) : 83 - 99
  • [2] ARTEETHER, A NEW ANTIMALARIAL DRUG - SYNTHESIS AND ANTIMALARIAL PROPERTIES
    BROSSI, A
    VENUGOPALAN, B
    GERPE, LD
    YEH, HJC
    FLIPPENANDERSON, JL
    BUCHS, P
    LUO, XD
    MILHOUS, W
    PETERS, W
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (03) : 645 - 650
  • [3] Study of artemisinin nanocapsules as anticancer drug delivery systems
    Chen, Youfang
    Lin, Xianfu
    Park, Hyunjin
    Greever, Richard
    [J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2009, 5 (03) : 316 - 322
  • [4] Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron
    Efferth, T
    Benakis, A
    Romero, MR
    Tomicic, M
    Rauh, R
    Steinbach, D
    Häfer, R
    Stamminger, T
    Oesch, F
    Kaina, B
    Marschall, M
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 2004, 37 (07) : 998 - 1009
  • [5] Efferth T, 2001, INT J ONCOL, V18, P767
  • [6] Haynes RK, 2002, EUR J ORG CHEM, V2002, P113
  • [7] QINGHAOSU (ARTEMISININ) - AN ANTIMALARIAL DRUG FROM CHINA
    KLAYMAN, DL
    [J]. SCIENCE, 1985, 228 (4703) : 1049 - 1055
  • [8] SELECTIVE CANCER CELL CYTOTOXICITY FROM EXPOSURE TO DIHYDROARTEMISININ AND HOLOTRANSFERRIN
    LAI, H
    SINGH, NP
    [J]. CANCER LETTERS, 1995, 91 (01) : 41 - 46
  • [9] THE CHEMISTRY, PHARMACOLOGY, AND CLINICAL-APPLICATIONS OF QINGHAOSU (ARTEMISININ) AND ITS DERIVATIVES
    LUO, XD
    SHEN, CC
    [J]. MEDICINAL RESEARCH REVIEWS, 1987, 7 (01) : 29 - 52
  • [10] A renewed assault on an old and deadly foe
    Marshall, E
    [J]. SCIENCE, 2000, 290 (5491) : 428 - 430
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