Safety of ginger use in pregnancy: results from a large population-based cohort study

被引:50
作者
Heitmann, Kristine [1 ,2 ]
Nordeng, Hedvig [3 ,4 ]
Holst, Lone [1 ,2 ]
机构
[1] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5020 Bergen, Norway
[2] Univ Bergen, Ctr Pharm, N-5020 Bergen, Norway
[3] Univ Oslo, Dept Pharm, Sch Pharm, Oslo, Norway
[4] Norwegian Inst Publ Heath, Div Mental Hlth, Bergen, Norway
关键词
Pregnancy; Ginger; Nausea; Herbal medicine; Congenital malformations; Pregnancy outcome; MEDICAL BIRTH REGISTRY; ALTERNATIVE MEDICINE; PLATELET-AGGREGATION; HERBAL REMEDIES; NAUSEA; COMPLEMENTARY; NORWAY; TRENDS; ONION;
D O I
10.1007/s00228-012-1331-5
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The objective of the study was to examine the safety of ginger use during pregnancy on congenital malformations and selected pregnancy outcomes. The Norwegian Mother and Child Cohort study, a large population-based cohort, provided the data used in this study. Our study population consisted of 68,522 women. Data on ginger use and socio-demographic factors were retrieved from three self-administered questionnaires completed by the women during weeks 17 and 30 of the pregnancy and when their child was 6 months old. Data on pregnancy outcomes were provided by the Medical Birth Registry of Norway. Among the 68,522 women in the study, 1,020 (1.5 %) women reported using ginger during pregnancy. The use of ginger during pregnancy was not associated with any increased risk of congenital malformations. No increased risk for stillbirth/perinatal death, preterm birth, low birth weight, or low Apgar score was detected for the women exposed to ginger during pregnancy compared to women who had not been exposed. Use of ginger during pregnancy does not seem to increase the risk of congenital malformations, stillbirth/perinatal death, preterm birth, low birth weight, or low Apgar score. This finding is clinically important for health care professionals giving advice to pregnant women with NPV.
引用
收藏
页码:269 / 277
页数:9
相关论文
共 49 条
[1]   Women's Use of Complementary and Alternative Medicine During Pregnancy: A Critical Review of the Literature [J].
Adams, Jon ;
Lui, Chi-Wai ;
Sibbritt, David ;
Broom, Alex ;
Wardle, Jon ;
Homer, Caroline ;
Beck, Shoshannah .
BIRTH-ISSUES IN PERINATAL CARE, 2009, 36 (03) :237-245
[2]  
[Anonymous], 2012, NAT MED COMPR DAT GI
[3]  
[Anonymous], RES TOOL KIT STAT PO
[4]   GINGER IN PREVENTING NAUSEA AND VOMITING OF PREGNANCY - A CAVEAT DUE TO ITS THROMBOXANE SYNTHETASE-ACTIVITY AND EFFECT ON TESTOSTERONE BINDING [J].
BACKON, J .
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 1991, 42 (02) :163-163
[5]  
Blumenthal M, 2000, EXPANDED COMISSION E
[6]   Effect of ginger (Zingiber officinale Rosc) and fenugreek (Trigonella foenumgraecum L) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease [J].
Bordia, A ;
Verma, SK ;
Srivastava, KC .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1997, 56 (05) :379-384
[7]  
BRAMER G R, 1988, World Health Statistics Quarterly, V41, P32
[8]  
Briggs G.G., 2008, DRUGS PREGNANCY LACT, V8th
[9]  
Chittumma Porndee, 2007, Journal of the Medical Association of Thailand, V90, P15
[10]   Trends in alternative medicine use in the United States, 1990-1997 - Results of a follow-up national survey [J].
Eisenberg, DM ;
Davis, RB ;
Ettner, SL ;
Appel, S ;
Wilkey, S ;
van Rompay, M ;
Kessler, RC .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (18) :1569-1575