Boron analysis and boron imaging in biological materials for Boron Neutron Capture Therapy (BNCT)

被引：114

作者：

Wittig, Andrea ^{[1
]}

Michel, Jean ^{[2
]}

Moss, Raymond L. ^{[3
]}

Stecher-Rasmussen, Finn ^{[4
]}

Arlinghaus, Heinrich F. ^{[5
]}

Bendel, Peter ^{[6
]}

Mauri, Pier Luigi ^{[7
]}

Altieri, Saverio ^{[8
,9
]}

Hilger, Ralf ^{[10
]}

Salvadori, Piero A. ^{[11
]}

Menichetti, Luca ^{[11
]}

Zamenhof, Robert ^{[12
,13
]}

Sauerwein, Wolfgang A. G. ^{[1
]}

机构：

[1] Univ Duisburg Essen, Dept Radiat Oncol, Univ Hosp Essen, D-45122 Essen, Germany

[2] Univ Reims, INSERM, Lab Microscop Elect Analyt, ERM 0203, Reims, France

[3] European Commiss, HFR Unit, Inst Energy, Joint Res Ctr, Petten, Netherlands

[4] NCT Phys, Alkmaar, Netherlands

[5] Univ Munster, Inst Phys, D-4400 Munster, Germany

[6] Weizmann Inst Sci, Chem Res Support Dept, IL-76100 Rehovot, Israel

[7] Inst Biomed Technol, Prote & Metab Unit, Milan, Italy

[8] Univ Pavia, Dept Nucl & Theoret Phys, I-27100 Pavia, Italy

[9] Ist Nazl Fis Nucl, Pavia Sect, I-27100 Pavia, Italy

[10] Univ Duisburg Essen, Dept Med Oncol, Univ Hosp Essen, D-45122 Essen, Germany

[11] CNR, Inst Clin Physiol, Dept PET & Radiopharmaceut Chem, I-56100 Pisa, Italy

[12] Indiana Univ, Midw Proton Radiotherapy Inst, Bloomington, IN USA

[13] Indiana Univ, Dept Phys, Bloomington, IN USA

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2008年 / 68卷 / 01期

关键词：

Prompt Gamma-ray Spectroscopy; Inductively Coupled Plasma Mass Spectroscopy; Neutron Capture Radiogaphy; laser-SNMS; Electron Energy Loss Spectroscopy; Ion Trap Mass Spectrometry; Nuclear Magnetic Resonance; Positron Emission Tomography;

D O I：

10.1016/j.critrevonc.2008.03.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Boron Neutron Capture Therapy (BNCT) is based on the ability of the stable isotope B-10 to capture neutrons, which leads to a nuclear reaction producing an alpha- and a Li-7-particle, both having a high biological effectiveness and a very short range in tissue, being limited to approximately one cell diameter. This opens the possibility for a highly selective cancer therapy. BNCT strongly depends oil the selective uptake of B-10 in tumor cells and on its distribution inside the cells. The chemical properties of boron and the need to discriminate different isotopes make the investigation of the concentration and distribution of B-10 a challenging task. The most advanced techniques to measure and image boron are described, both invasive and non-invasive. The most promising approach for further investigation will be the complementary use of the different techniques to obtain the information that is mandatory for the future of this innovative treatment modality. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：66 / 90

页数：25

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